Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway.
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DOI: 10.1073/pnas.2120403119
Abstract: SignificanceVHL tumor suppressor gene inactivation is a hallmark of clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, and promotes tumor growth by stabilizing the hypoxia-inducible factor 2 (HIF2) transcription factor.… read more here.
Keywords: hif2 inhibitors; p53; p53 pathway; intact p53 ... See more keywords