Hyaluronanâbased dissolving microneedles with high antigen content for intradermal vaccination: Formulation, physicochemical characterization and immunogenicity assessment
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.11.013
Abstract: Graphical abstract Figure. No caption available. Abstract The purpose of this study was to optimize the manufacturing of dissolving microneedles (dMNs) and to increase the antigen loading in dMNs to investigate the effect on their… read more here.
Keywords: dissolving microneedles; high antigen; antigen; intradermal vaccination ... See more keywords
Unraveling the Hook Effect: A Comprehensive Study of High Antigen Concentration Effects in Sandwich Lateral Flow Immunoassays
Sign Up to like & getrecommendations! Published in 2020 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.0c03740
Abstract: Sandwich lateral flow immunoassays (LFIAs) are limited at high antigen concentrations by the hook effect, leading to a contradictory decrease in the test line (T) intensity and false-negative results. The hook effect is mainly associated… read more here.
Keywords: hook effect; high antigen; antigen; antigen concentration ... See more keywords