Single-Cell and Population Transcriptomics Reveal Pan-epithelial Remodeling in Type 2-High Asthma
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DOI: 10.1016/j.celrep.2020.107872
Abstract: SUMMARY The type 2 cytokine-high asthma endotype (T2H) is characterized by IL-13-driven mucus obstruction of the airways. To further investigate this incompletely understood pathobiology, we characterize IL-13 effects on human airway epithelial cell cultures using… read more here.
Keywords: single cell; population transcriptomics; cell population; high asthma ... See more keywords
When one plus one means more than two: the blockade of both IL-4 and IL-13 inflammatory pathways with dupilumab in a case of severe refractory T2-high asthma
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Case Reports"
DOI: 10.1136/bcr-2021-244503
Abstract: Novel approach of asthma includes personalised therapy involving specific immune pathways. We describe here a case of T2-high asthma in a 66-year-old woman treated with maximal inhaled therapy and inappropriate usage of oral corticosteroids showing… read more here.
Keywords: asthma; one plus; one means; high asthma ... See more keywords
Epithelial miR-206 targets CD39/extracellular ATP to upregulate airway IL-25 and TSLP in type 2–high asthma
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DOI: 10.1172/jci.insight.148103
Abstract: The epithelial cell–derived cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) initiate type 2 inflammation in allergic diseases, including asthma. However, the signaling pathway regulating these cytokines expression remains elusive. Since microRNAs are pivotal regulators… read more here.
Keywords: type high; mir 206; high asthma; expression ... See more keywords
Inflammation in Asthma: Mechanistic Insights and the Role of Biologics in Therapeutic Frontiers
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DOI: 10.3390/biomedicines13061342
Abstract: Asthma is a chronic and multifaceted respiratory condition that affects over 300 million individuals across the globe. It is characterized by persistent inflammation of the airways, which leads to episodes of wheezing, breathlessness, chest tightness,… read more here.
Keywords: high asthma; low asthma; inflammation asthma; asthma mechanistic ... See more keywords