The potential significance of high avidity immunoglobulin G (IgG) for protective immunity towards SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2021.01.061
Abstract: Background Avidity is defined as the strength of binding between IgG and its specific target epitope. IgG of high avidity is established during affinity maturation. A failure to achieve high avidity IgG may result in… read more here.
Keywords: avidity; towards sars; high avidity; sars cov ... See more keywords
A High-Avidity, Thermostable, and Low-Cost Synthetic Capture for Ultrasensitive Detection and Quantification of Viral Antigens and Aerosols.
Sign Up to like & getrecommendations! Published in 2024 at "ACS sensors"
DOI: 10.1021/acssensors.4c00282
Abstract: Lateral flow assays (LFAs) are currently the most popular point-of-care diagnostics, rapidly transforming disease diagnosis from expensive doctor checkups and laboratory-based tests to potential on-the-shelf commodities. Yet, their sensitive element, a monoclonal antibody, is expensive… read more here.
Keywords: bsa; synthetic capture; high avidity; lcb1 bsa ... See more keywords
Design of high-avidity multivalent ligand structures that target cells with high ligand economy.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03296a
Abstract: Novel cell-targeting ligand structures are constructed with a spikey core scaffold, where multiple copies of coiled-coil peptide nanorods are conjugated on the surface of a peptide nanosheet. Clustering of carbohydrate and aptamer ligands at the… read more here.
Keywords: ligand structures; avidity multivalent; high avidity; ligand ... See more keywords
Identification of shared tumor epitopes from endogenous retroviruses inducing high-avidity cytotoxic T cells for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abj3671
Abstract: Human endogenous retroviruses (HERVs) represent 8% of the human genome. HERV products may represent tumor antigens relevant for cancer immunotherapy. We developed a bioinformatic approach to identify shared CD8+ T cell epitopes derived from cancer-associated… read more here.
Keywords: cancer; high avidity; tumor; endogenous retroviruses ... See more keywords
CRISPR-based gene disruption and integration of high-avidity, WT1-specific T cell receptors improve antitumor T cell function
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abg8027
Abstract: T cell receptor (TCR)–based therapy has the potential to induce durable clinical responses in patients with cancer by targeting intracellular tumor antigens with high sensitivity and by promoting T cell survival. However, the need for… read more here.
Keywords: cell; tcr; high avidity; wt1 ... See more keywords
Natural high-avidity T-cell receptor efficiently mediates regression of cancer/testis antigen 83 positive common solid cancers
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004713
Abstract: Background T-cell receptor-engineered T cells (TCR-Ts) have achieved encouraging success in anticancer clinical trials. The antigenic targets, however, were primarily focused on human leukocyte antigen (HLA) A*02:01 restricted epitopes from a few cancer/testis antigens (CTAs)… read more here.
Keywords: cell; cancer; high avidity; common solid ... See more keywords
Abstract 608: Low avidity neoepitope-specific CD8+ tumor infiltrating lymphocytes are less exhausted and more effective than their high avidity counterparts in a BALB/c murine fibrosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-608
Abstract: The frequency of CD8+ tumor infiltrating lymphocytes (TILs) has been positively associated with overall survival in several cancers. The interaction of T cell receptors (TCRs) on T cells with Major Histocompatibility Complex (MHC)-peptide complexes on… read more here.
Keywords: low avidity; high avidity; term; cd8 tils ... See more keywords
T cell priming by high avidity neoantigens in lymph nodes augments adoptive immunotherapy.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-25-0514
Abstract: Adoptive transfer of T lymphocytes specific for tumor-associated neoantigens can elicit immunity against solid tumors in patients. However, how these antigens impact T cell function, effector differentiation, and persistence remains unclear. We examined how an… read more here.
Keywords: high avidity; lymph nodes; cell; tumor ... See more keywords
High-avidity binding drives nucleation of amyloidogenic transthyretin monomer
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.150131
Abstract: Amyloidosis involves stepwise growth of fibrils assembled from soluble precursors. Transthyretin (TTR) naturally folds into a stable tetramer, whereas conditions and mutations that foster aberrant monomer formations facilitate TTR oligomeric aggregation and subsequent fibril extension.… read more here.
Keywords: binding drives; ttr; avidity binding; monomer ... See more keywords
CD3 downregulation identifies high-avidity, multipotent SARS-CoV-2 vaccine– and recall antigen–specific Th cells with distinct metabolism
Sign Up to like & getrecommendations! Published in 2024 at "JCI Insight"
DOI: 10.1172/jci.insight.166833
Abstract: Functional avidity is supposed to critically shape the quality of immune responses, thereby influencing host protection against infectious agents including SARS-CoV-2. Here we show that after human SARS-CoV-2 vaccination, a large portion of high-avidity spike-specific… read more here.
Keywords: sars cov; high avidity; cd3; recall antigen ... See more keywords
Virus-Specific Secondary Plasma Cells Produce Elevated Levels of High-Avidity Antibodies but Are Functionally Short Lived
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01831
Abstract: Most vaccines aim at inducing durable antibody responses and are designed to elicit strong B cell activation and plasma cell (PC) formation. Here we report characteristics of a recently described secondary PC population that rapidly… read more here.
Keywords: avidity; high avidity; avidity antibodies; secondary pcs ... See more keywords