Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation
Sign Up to like & getrecommendations! Published in 2017 at "Calcified Tissue International"
DOI: 10.1007/s00223-017-0338-4
Abstract: Wnt antagonist Dkk1 is a negative regulator of bone formation and Dkk1+/− heterozygous mice display a high bone mass phenotype. Complete loss of Dkk1 function disrupts embryonic head development. Homozygous Dkk1−/− mice that were heterozygous… read more here.
Keywords: phenotype; bone formation; dkk1; bone ... See more keywords
Individuals with High Bone Mass have increased progression of radiographic and clinical features of knee osteoarthritis.
Sign Up to like & getrecommendations! Published in 2020 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2020.03.020
Abstract: OBJECTIVE High bone mass (HBM) is associated with an increased prevalence of radiographic knee OA (kOA), characterized by osteophytosis. We aimed to determine if progression of radiographic kOA, and its sub-phenotypes, is increased in HBM… read more here.
Keywords: bone mass; progression; high bone; bone ... See more keywords