The reason for a high Ca2+-sensitivity associated with Arg91Gly substitution in TPM2 gene is the abnormal behavior and high flexibility of tropomyosin during the ATPase cycle.
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DOI: 10.1016/j.bbrc.2017.10.161
Abstract: Substitution of Arg for Gly residue in 91th position in β-tropomyosin caused by a point mutation in TPM2 gene is associated with distal arthrogryposis, characterized by a high Ca2+-sensitivity of myofilament and contracture syndrome. To… read more here.
Keywords: high ca2; tropomyosin; ca2 sensitivity; atpase cycle ... See more keywords