High-Confidence Protein-Ligand Complex Modeling by NMR-Guided Docking Enables Early Hit Optimization.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b07171
Abstract: Structure-based drug design is an integral part of modern day drug discovery and requires detailed structural characterization of protein-ligand interactions, which is most commonly performed by X-ray crystallography. However, the success rate of generating these… read more here.
Keywords: guided docking; high confidence; optimization; ligand ... See more keywords
Best practices for benchmarking germline small-variant calls in human genomes
Sign Up to like & getrecommendations! Published in 2019 at "Nature Biotechnology"
DOI: 10.1038/s41587-019-0054-x
Abstract: Standardized benchmarking approaches are required to assess the accuracy of variants called from sequence data. Although variant-calling tools and the metrics used to assess their performance continue to improve, important challenges remain. Here, as part… read more here.
Keywords: variant calling; high confidence; variant calls; variant ... See more keywords
Identifying High Confidence microRNAs in the Developing Seeds of Jatropha curcas
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41189-y
Abstract: MicroRNAs (miRNAs) are endogenously short noncoding regulatory RNAs implicated in plant development and physiology. Nine small RNA (sRNA) libraries from three typical seed developmental stages (young, intermediate, and mature) were generated by deep sequencing to… read more here.
Keywords: seed; high confidence; developing seeds; development ... See more keywords
Blockchain-Enhanced High-Confidence Energy Sharing in Internet of Electric Vehicles
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Internet of Things Journal"
DOI: 10.1109/jiot.2020.2992994
Abstract: To introduce the opportunities brought by plug-in hybrid electric vehicles (PHEVs) to the energy Internet, we propose a local vehicle-to-vehicle (V2V) energy trading architecture based on fog computing in social hotspots and model the social… read more here.
Keywords: blockchain enhanced; enhanced high; high confidence; electric vehicles ... See more keywords
Evaluating High-Confidence Genes in Conotruncal Cardiac Defects by Gene Burden Analyses.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Heart Association"
DOI: 10.1161/jaha.122.028226
Abstract: Background In nonsyndromic conotruncal cardiac defects, the use of next-generation sequencing for clinical diagnosis is increasingly adopted, but gene-disease associations in research are only partially translated to diagnostic panels, suggesting a need for evidence-based consensus.… read more here.
Keywords: burden analyses; high confidence; conotruncal cardiac; gene ... See more keywords
Identification of high-confidence RNA regulatory elements by combinatorial classification of RNA–protein binding sites
Sign Up to like & getrecommendations! Published in 2017 at "Genome Biology"
DOI: 10.1186/s13059-017-1298-8
Abstract: Crosslinking immunoprecipitation sequencing (CLIP-seq) technologies have enabled researchers to characterize transcriptome-wide binding sites of RNA-binding protein (RBP) with high resolution. We apply a soft-clustering method, RBPgroup, to various CLIP-seq datasets to group together RBPs that… read more here.
Keywords: protein; high confidence; rna; binding sites ... See more keywords
Integrating Genome-Wide CNVs Into QTLs and High Confidence GWAScore Regions Identified Positional Candidates for Sheep Economic Traits
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.00569
Abstract: Copy number variations (CNVs) are important source of genetic variation, which can affect diverse economic traits through a variety of mechanisms. In addition, genome scan can identify many quantitative trait loci (QTLs) for the economic… read more here.
Keywords: genome wide; economic traits; high confidence; confidence gwascore ... See more keywords