Microstructure and Mechanical Properties of the As‐Cast AlLiCuMgZr Alloy with High Li Content and Different Cu/Mg Ratios
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Engineering Materials"
DOI: 10.1002/adem.201901570
Abstract: The microstructures and mechanical properties of as‐cast AlLiCuMgZr alloys with high Li content and different Cu/Mg ratios are investigated. The results show that the tensile strength increases and the elongation almost keeps unchanged, with the… read more here.
Keywords: phase; high content; content different; properties cast ... See more keywords
3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing
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DOI: 10.1002/advs.201800927
Abstract: Abstract Parkinson's disease (PD)‐specific neurons, grown in standard 2D cultures, typically only display weak endophenotypes. The cultivation of PD patient‐specific neurons, derived from induced pluripotent stem cells carrying the LRRK2‐G2019S mutation, is optimized in 3D… read more here.
Keywords: disease specific; lrrk2 g2019s; drug; parkinson disease ... See more keywords
Getting the whole picture: High content screening using three‐dimensional cellular model systems and whole animal assays
Sign Up to like & getrecommendations! Published in 2017 at "Cytometry Part A"
DOI: 10.1002/cyto.a.22907
Abstract: Phenotypic or High Content Screening (HCS) is becoming more widely used for primary screening campaigns in drug discovery. Currently the vast majority of HCS campaigns are using cell lines grown in well‐established monolayer cultures (2D… read more here.
Keywords: animal assays; tissue culture; whole animal; content screening ... See more keywords
Microencapsulation of High-Content Actives Using Biodegradable Silk Materials.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202201487
Abstract: There is a compelling need across several industries to substitute non-degradable, intentionally added microplastics with biodegradable alternatives. Nonetheless, stringent performance criteria in actives' controlled release and manufacturing at scale of emerging materials hinder the replacement… read more here.
Keywords: silk; silk fibroin; content actives; microencapsulation high ... See more keywords
Generation and Analysis of Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells for High Content Screening Purposes.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/7651_2019_222
Abstract: Human-induced pluripotent stem cells (hiPSCs) and their differentiated derivatives became a new, promising source for in vitro screening techniques. Cell lines derived from healthy individuals can be applied for drug safety testing, while patient-derived cells… read more here.
Keywords: cardiomyocytes endothelial; high content; analysis; pluripotent stem ... See more keywords
Utilization of Multidimensional Data in the Analysis of Ultra-High-Throughput High Content Phenotypic Screens.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7357-6_16
Abstract: High Content Screening (HCS) platforms can generate large amounts of multidimensional data. To take full advantage of all the rich contextual information provided by these screens, a combination of traditional as well as nontraditional hit… read more here.
Keywords: data analysis; utilization multidimensional; content; analysis ultra ... See more keywords
High Content Screening of Mammalian Primary Cortical Neurons.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7357-6_17
Abstract: High Content Screening (HCS) can be used to analyze the morphology of neuronal primary cultures on a large scale. When used in the field of neuronal regeneration this approach allows the screening of hundreds or… read more here.
Keywords: content screening; primary cortical; mammalian primary; screening mammalian ... See more keywords
High-Content Reporter Assays.
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DOI: 10.1007/978-1-4939-7724-6_13
Abstract: While luminescent reporter gene assays allow for a rapid and relatively interference free assessment of the activation state of a luminescent reporter, fluorescent reporters do not. They suffer from artifacts such as compound fluorescence and… read more here.
Keywords: reporter; reporter assays; biology; content reporter ... See more keywords
High-Content Analysis of Mitochondrial Function in iPSC-Derived Neurons.
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DOI: 10.1007/978-1-4939-9477-9_16
Abstract: Mitochondrial dysfunction is linked to many neurological diseases; therefore, the ability to measure mitochondrial function is of great use for researching disease and testing potential therapeutics. Here we describe a high-content assay to simultaneously measure… read more here.
Keywords: mitochondrial function; analysis; derived neurons; ipsc derived ... See more keywords
Morphometric Characterization of Rat and Human Alveolar Macrophage Cell Models and their Response to Amiodarone using High Content Image Analysis
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Research"
DOI: 10.1007/s11095-017-2176-5
Abstract: PurposeProgress to the clinic may be delayed or prevented when vacuolated or “foamy” alveolar macrophages are observed during non-clinical inhalation toxicology assessment. The first step in developing methods to study this response in vitro is… read more here.
Keywords: response; high content; analysis; macrophage ... See more keywords
Use of the High-Content Imaging System equipment to evaluate in vitro infection by Leishmania braziliensis in response to sand fly Nyssomyia neivai saliva.
Sign Up to like & getrecommendations! Published in 2020 at "Acta tropica"
DOI: 10.1016/j.actatropica.2020.105540
Abstract: Earlier research has shown that in vivo immunization with sand fly saliva protects the host against infection by parasites of genus Leishmania, and inoculation of saliva along with Leishmania promastigotes favors infection in the host.… read more here.
Keywords: sand fly; infection; content imaging; high content ... See more keywords