Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112355
Abstract: In this work, unique flavopiridol analogs bearing thiosugars, amino acids and heterocyclic moieties tethered to the flavopiridol via thioether and amine bonds mainly on its C ring have been prepared. The analogs bearing thioether-benzimidazoles as… read more here.
Keywords: identification new; cytotoxic; flavopiridol like; series flavopiridol ... See more keywords
Satraplatin Demonstrates High Cytotoxic Activity Against Genetically Defined Lymphoid Malignancies
Sign Up to like & getrecommendations! Published in 2022 at "AntiCancer Research"
DOI: 10.21873/anticanres.15658
Abstract: Background/Aim: Satraplatin is an oral platinum analog with proven clinical efficacy and a more favorable toxicity profile, although with increased hematotoxicity, when compared to cisplatin. Hence, we carried out a systematic biomarker analysis to identify… read more here.
Keywords: cytotoxic activity; cell; high cytotoxic; activity genetically ... See more keywords