Liquid Metal‐Enabled Microspheres with High Drug Loading and Multimodal Imaging for Artery Embolization
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202209413
Abstract: The drug‐eluting microspheres that have been widely used in clinical treatments such as chemoembolization commonly suffer from inadequate drug loading and tracking difficulties. With inherent high density and excellent biocompatibility, liquid metal (LM) has been… read more here.
Keywords: liquid metal; high drug; multimodal imaging; embolization ... See more keywords
Two-Dimensional Ultra-Thin Nanosheets with Extraordinarily High Drug Loading and Long Blood Circulation for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202200299
Abstract: Nanoparticle drug delivery is largely restricted by the low drug loading capacity of nanoparticle carriers. To address this critical challenge and maximize the potential of nanoparticle drug delivery, a 2D ultra-thin layered double hydroxide (LDH)… read more here.
Keywords: high drug; blood circulation; ultra thin; drug ... See more keywords
Acid-activatable doxorubicin prodrug micelles with folate-targeted and ultra-high drug loading features for efficient antitumor drug delivery
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Materials Science"
DOI: 10.1007/s10853-017-1546-z
Abstract: Stimuli-responsive nanomedicine shows high therapeutic effects and low side effects to tumor cells and tissues, representing a preferable therapeutics for cancer therapy. Herein, we design an acid-stimuli-responsive doxorubicin polymeric prodrug (OM@DOX), and this amphiphilic prodrug… read more here.
Keywords: tumor cells; drug; prodrug; high drug ... See more keywords
Formulation of pH-responsive PEGylated nanoparticles with high drug loading capacity and programmable drug release for enhanced antibacterial activity
Sign Up to like & getrecommendations! Published in 2022 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2022.02.018
Abstract: In the current global crisis of antibiotic resistance, delivery systems are emerging to combat resistant bacteria in a more efficient manner. Despite the significant advances of antibiotic nanocarriers, many challenges like poor biocompatibility, premature drug… read more here.
Keywords: van; drug; high drug; activity ... See more keywords
Chemically identical but physically different: A comparison of spray drying, hot melt extrusion and cryo‐milling for the formulation of high drug loaded amorphous solid dispersions of naproxen
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.12.002
Abstract: Graphical abstract Figure. No Caption available. Abstract In spite of the large research efforts in the past two decades, it is still difficult, if possible at all, to predict what manufacturing technology will lead to… read more here.
Keywords: drug; high drug; melt extrusion; hot melt ... See more keywords
A novel high drug loading mussel-inspired polydopamine hybrid nanoparticle as a pH-sensitive vehicle for drug delivery.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.09.058
Abstract: A novel high drug loading pH-cleavable polymer hybrid nanoparticle was prepared via doxorubicin (DOX) grafted onto PEGylated, mussel-inspired polydopamine (PDA) and then coated onto hollow silica nanoparticles for drug delivery. A series of characterization shed… read more here.
Keywords: drug loading; novel high; drug delivery; drug ... See more keywords
Improved properties of fine active pharmaceutical ingredient powder blends and tablets at high drug loading via dry particle coating
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.04.002
Abstract: &NA; It has been shown that dry coating cohesive active pharmaceutical ingredients (APIs) with nano‐silica can improve packing and flow of their blends, facilitating high speed direct compression tableting. This paper examines the broader scope… read more here.
Keywords: drug loading; active pharmaceutical; nano silica; particle ... See more keywords
A nanofiber-based drug depot with high drug loading for sustained release.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119397
Abstract: Nanostructures and their related structure-performance relationships for "efficacious, safe and convenient" drug delivery are playing a more and more important role in the fast development of nanopharmaceutics. In this study, a core-shell fiber based nano… read more here.
Keywords: drug loading; drug; sustained release; pubchemcid ... See more keywords
Design of dual-responsive nanocarries with high drug loading capacity based on hollow mesoporous organosilica nanoparticles
Sign Up to like & getrecommendations! Published in 2019 at "Materials Chemistry and Physics"
DOI: 10.1016/j.matchemphys.2019.05.025
Abstract: Abstract Pores and framework dual responsive controlled release systems with high drug loading capacity based on HMONs (DOX@HMONs/CD) have been prepared. The DOX@HMONs/CD show high loading capacity (1060 mg/g) for anticancer drug. The cumulative release of… read more here.
Keywords: drug; high drug; drug loading; capacity ... See more keywords
Co-delivery of dual chemo-drugs with precisely controlled, high drug loading polymeric micelles for synergistic anti-cancer therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c9bm01662g
Abstract: Simultaneous delivery of multiple chemotherapeutics using polymeric micelles often suffers from unsatisfactory drug loading, drug ratio management, and drug release. Herein, we report a feasible strategy to prepare micelles with ultra-high drug loading and a… read more here.
Keywords: drug loading; delivery; drug; cancer ... See more keywords
Porous Core/Dense Shell PLA Microspheres Embedded with High Drug Loading of Bupivacaine Crystals for Injectable Prolonged Release
Sign Up to like & getrecommendations! Published in 2021 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-020-01878-8
Abstract: Objective of the study was to design an injectable microsphere preparation with high drug loading of bupivacaine for prolonged release and local anesthetic. PLA or PLGA was used as the biodegradable matrix material to fabricate… read more here.
Keywords: pla; drug; bupivacaine; shell ... See more keywords