Early use of high-efficacy therapies in multiple sclerosis in the United States: benefits, barriers, and strategies for encouraging adoption
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neurology"
DOI: 10.1007/s00415-024-12305-4
Abstract: Multiple sclerosis (MS) is characterized by progressive neuroinflammation and neurodegeneration from disease onset that, if left untreated, can result in the accumulation of irreversible neurological disability. Early intervention with high-efficacy therapies (HETs) is increasingly recognized… read more here.
Keywords: united states; multiple sclerosis; high efficacy; efficacy ... See more keywords
Bringing the HEET: The Argument for High-Efficacy Early Treatment for Pediatric-Onset Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2017 at "Neurotherapeutics"
DOI: 10.1007/s13311-017-0568-1
Abstract: Pediatric-onset multiple sclerosis (POMS) is rarer than adult-onset disease, and represents a different diagnostic and treatment challenge to clinicians. We review POMS clinical and radiographic presentations, and explore important differences between POMS and adult-onset MS… read more here.
Keywords: high efficacy; treatment; early treatment; efficacy early ... See more keywords
Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay.
Sign Up to like & getrecommendations! Published in 2024 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00836
Abstract: Activation of the GABAA receptor is associated with numerous behavioral end points ranging from anxiolysis to deep anesthesia. The specific behavioral effect of a GABAergic compound is considered to correlate with the degree of its… read more here.
Keywords: effect; high efficacy; zebrafish larvae; gabaa receptor ... See more keywords
High efficacy of microbial larvicides for malaria vectors control in the city of Yaounde Cameroon following a cluster randomized trial
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-96362-z
Abstract: The rapid expansion of insecticide resistance and outdoor malaria transmission are affecting the efficacy of current malaria control measures. In urban settings, where malaria transmission is focal and breeding habitats are few, fixed and findable,… read more here.
Keywords: trial; city; control; high efficacy ... See more keywords
Is there a role for off‐label high‐efficacy disease‐modifying drugs in progressive multiple sclerosis? A network meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Acta Neurologica Scandinavica"
DOI: 10.1111/ane.13697
Abstract: Ocrelizumab and siponimod are the two on‐label drugs used for progressive forms of multiple sclerosis (PMS). However, many patients with PMS do not have access to these high‐efficacy disease‐modifying drugs (DMDs). Off‐label prescription of other… read more here.
Keywords: network; label high; high efficacy; efficacy ... See more keywords
Secukinumab shows high efficacy irrespective of HLA‐Cw6 status in patients with moderate‐to‐severe plaque‐type psoriasis: SUPREME study
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Dermatology"
DOI: 10.1111/bjd.16705
Abstract: Understanding genetic variations is important in predicting treatment response and forms the basis for identifying new pharmacogenetic and pharmacogenomic targets for psoriasis treatment. There are limited data on the efficacy of secukinumab in relation to… read more here.
Keywords: efficacy irrespective; shows high; irrespective hla; high efficacy ... See more keywords
From diagnosis to treatment: patterns in disease-modifying therapy initiation in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Therapeutic Advances in Neurological Disorders"
DOI: 10.1177/17562864251398472
Abstract: Background: Over recent decades, several high-efficacy disease-modifying therapies (DMTs) have been approved for multiple sclerosis (MS), prompting a shift from an escalation strategy toward early high-efficacy treatment. Yet, DMT initiation patterns and safety profiles remain… read more here.
Keywords: diagnosis; high efficacy; first dmt; efficacy ... See more keywords
Voruciclib plus venetoclax show high efficacy for CLL b cells on human stromal cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e20009
Abstract: e20009Background: Although treating B-Chronic Lymphocytic Leukemia (CLL) with small molecule inhibitors has shown promise, a lasting cure for this disease has yet to be found. Further treatments di... read more here.
Keywords: cll; show high; venetoclax show; high efficacy ... See more keywords
Initial High-Efficacy Disease-Modifying Therapy in Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000201391
Abstract: In the Research Article “Initial High-Efficacy Disease-Modifying Therapy in Multiple Sclerosis: A Nationwide Cohort Study” by Buron et al.,1 2 authors were mistakenly omitted from the final manuscript. Dr. Danny Bech, MD, should appear as… read more here.
Keywords: therapy multiple; high efficacy; modifying therapy; disease modifying ... See more keywords
Risk of Cervical Abnormalities for Women With Multiple Sclerosis Treated With Moderate-Efficacy and High-Efficacy Disease-Modifying Therapies
Sign Up to like & getrecommendations! Published in 2024 at "Neurology"
DOI: 10.1212/wnl.0000000000208059
Abstract: Background and Objectives The impact of immunomodulatory therapies on the risk of cervical pre-cancer and invasive cancer development is important for the health and safety of women with multiple sclerosis (wwMS). We investigate the risk… read more here.
Keywords: risk cervical; cervical abnormalities; high efficacy; efficacy ... See more keywords
How to choose initial treatment in multiple sclerosis patients: a case-based approach
Sign Up to like & getrecommendations! Published in 2022 at "Arquivos de Neuro-Psiquiatria"
DOI: 10.1590/0004-282x-anp-2022-s128
Abstract: ABSTRACT Background: Immunotherapy dramatically changed the natural history of multiple sclerosis (MS), which was classically associated with severe disability. Treatment strategies advocate that early control of disease activity is crucial to avoid progressive disability, and… read more here.
Keywords: case based; high efficacy; based approach; efficacy ... See more keywords