Engineered Extracellular Vesicles with SHP2 High Expression Promote Mitophagy for Alzheimer's Disease Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202207107
Abstract: Mitochondrial dysfunction is a fundamental pathological feature of Alzheimer's disease (AD). However, toxicity and poor brain enrichment of existing mitophagy inducers limit their further applications. In this study, a platform for AD therapy is developed… read more here.
Keywords: extracellular vesicles; alzheimer disease; high expression; mitophagy ... See more keywords
Reduced distractor interference in neurotypical adults with high expression of autistic traits irrespective of stimulus type
Sign Up to like & getrecommendations! Published in 2018 at "Autism Research"
DOI: 10.1002/aur.2005
Abstract: Attention atypicality is evident in autism spectrum disorder (ASD) and its broader phenotype with previous studies suggesting that in some cases participants can be more efficient at ignoring distracting irrelevant information. However, it is not… read more here.
Keywords: autistic traits; autism; expression autistic; distractor ... See more keywords
High expression of DJ‐1 promotes growth and invasion via the PTEN‐AKT pathway and predicts a poor prognosis in colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1325
Abstract: Cancer cell invasion and unlimited proliferation are key factors in patients with colorectal cancer (CRC). Increased protein deglycase DJ‐1 in cancer cells is known to promote tumor growth; however, its role in CRC progression is… read more here.
Keywords: invasion; colorectal cancer; crc; cancer ... See more keywords
High expression of caspase‐8 as a predictive factor of poor prognosis in patients with esophageal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5496
Abstract: Esophageal carcinoma (ESCA) is considered to be one of the most common gastrointestinal cancers. Caspase‐8 (CASP8) is a key protein of cross‐talk signaling in a variety of cancers. However, the role of CASP8 expression in… read more here.
Keywords: high expression; expression caspase; expression; prognosis patients ... See more keywords
High expression of LOC541471, GDAP1, SOD1, and STK25 is associated with poor overall survival of patients with acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5644
Abstract: Acute myeloid leukemia (AML) is an aggressive heterogeneous hematological malignancy with remarkably heterogeneous outcomes. This study aimed to identify potential biomarkers for AML risk stratification via analysis of gene expression profiles. read more here.
Keywords: acute myeloid; myeloid leukemia; high expression; expression loc541471 ... See more keywords
Real‐world first‐line treatment with pembrolizumab for non‐small cell lung carcinoma with high PD‐L1 expression: Updated analysis
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.70036
Abstract: Selecting pembrolizumab monotherapy (MONO) or pembrolizumab plus platinum‐based chemotherapy (COMB) for patients with nonsmall cell lung cancer (NSCLC) and high programmed death‐ligand 1 (PD‐L1) expression is an important issue in clinical practice. We previously conducted… read more here.
Keywords: pembrolizumab; high expression; cell lung; first line ... See more keywords
Pleural CD14+ monocytes/macrophages of healthy adolescents show a high expression of metallothionein family genes
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202250019
Abstract: Nowadays laparoscopic interventions enable the collection of resident macrophage populations out of the human cavities. We employed this technique to isolate pleural monocytes/macrophages from healthy young adults who underwent a correction of pectus excavatum. High… read more here.
Keywords: macrophages healthy; cd14 monocytes; monocytes macrophages; high expression ... See more keywords
The PD‐1/PD‐L1 axis and human papilloma virus in patients with head and neck cancer after adjuvant chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK‐ROG)
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30770
Abstract: We examined the prognostic role of PD‐1+ and CD8+ tumor infiltrating lymphocytes (TILs), and PD‐L1+ cells in patients with squamous cell carcinoma of the head and neck (SCCHN) treated with surgery and postoperative chemoradiotherapy (CRT).… read more here.
Keywords: chemoradiotherapy; oncology; cancer; high expression ... See more keywords
Recent Insights Into Wnt‐Related tRNA‐Derived Fragments (tRFs) in Human Diseases
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DOI: 10.1002/jcb.30702
Abstract: tRNA‐derived fragments (tRFs) are a newly recognized class of small noncoding RNAs (sncRNAs) that play significant roles in various diseases. The Wnt pathway plays a key role in various physiological processes such as embryonic development,… read more here.
Keywords: high expression; derived fragments; expression; low expression ... See more keywords
High expression of FAM13A was associated with increasing the liver cirrhosis risk
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.543
Abstract: Liver cirrhosis is a consequence of chronic liver disease, and it may be caused by multiple influences of both genetic and environmental factors. Family with sequence similarity 13 member A (FAM13A) has been previously associated… read more here.
Keywords: high expression; cirrhosis; liver cirrhosis; expression fam13a ... See more keywords
Engineered Cytokine-Primed Extracellular Vesicles with High PD-L1 Expression Ameliorate Type 1 Diabetes.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202301019
Abstract: Type 1 diabetes (T1D), which is a chronic autoimmune disease, results from the destruction of insulin-producing β cells targeted by autoreactive T cells. The recent discovery that mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) function as… read more here.
Keywords: engineered cytokine; extracellular vesicles; cytokine primed; high expression ... See more keywords