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   Articles with "high fat" as a keyword



Loss of EGFR contributes to high-fat diet-induced nonalcoholic fatty liver disease.

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recommendations! Published in 2023 at "FEBS letters"

DOI: 10.1002/1873-3468.14636

Abstract: Using a murine model of high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD), we found that the expression of the epidermal growth factor receptor (EGFR) significantly decreased in hepatocytes. In vitro, free fatty acid influx… read more here.

Keywords: fatty liver; high fat; egfr; liver disease ... See more keywords

Effects of high‐fat diet‐induced adipokines and cytokines on colorectal cancer development

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recommendations! Published in 2019 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12751

Abstract: Colorectal cancer (CRC) is the third most common tumor worldwide, and recent epidemiological studies have indicated that obesity contributes to the morbidity and mortality of CRC. Furthermore, obesity‐related adipokines have been shown to be closely… read more here.

Keywords: fat diet; diet induced; adipokines cytokines; induced adipokines ... See more keywords

In‐depth multiomic characterization of the effects of obesity in high‐fat diet‐fed mice

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recommendations! Published in 2024 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13788

Abstract: High‐fat diet (HFD)‐fed mice have been widely used in the clinical investigation of obesity. However, the long‐term effect of HFD on gut microbiota and metabolites, plasma and liver metabolomics, colonic and liver transcriptomics remain largely… read more here.

Keywords: mice; fat diet; fed mice; metabolism ... See more keywords

High‐Fat and Low‐Carbohydrate Dietary Environments Are Linked to Reduced Idiopathic Epilepsy Incidence and Prevalence

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recommendations! Published in 2025 at "Annals of Clinical and Translational Neurology"

DOI: 10.1002/acn3.70017

Abstract: Dietary manipulations like ketogenic diets are established interventions for recalcitrant epilepsy. However, it remains unknown whether specific macronutrient exposure through dietary environments could possibly extend to primary preventive qualities, associated with changes in epilepsy disease… read more here.

Keywords: dietary environments; epilepsy; idiopathic epilepsy; incidence ... See more keywords

Microglial Feimin Alleviates Cognitive Impairment in High-Fat Diet-Fed Mice.

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recommendations! Published in 2025 at "Advanced science"

DOI: 10.1002/advs.202512023

Abstract: Lipid droplet accumulation in microglia, microglia‐mediated neuroinflammation, and subsequent neuronal damage are hallmark features of high‐fat diet (HFD)‐induced cognitive impairment. In this analysis, this is proposed that a new molecule feimin (B230219D22Rik in mice) is… read more here.

Keywords: mice; cognitive impairment; accumulation; fat diet ... See more keywords
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The effects of high-fat diet and metformin on urinary metabolites in diabetes and pre-diabetes rat models.

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recommendations! Published in 2020 at "Biotechnology and applied biochemistry"

DOI: 10.1002/bab.2021

Abstract: High-fat diet (HFD) interferes with the dietary plan of patients with type 2 diabetes mellitus (T2DM). However, many diabetes patients consume food with higher fat content for a better taste bud experience. In this study,… read more here.

Keywords: fat diet; pre diabetes; hfd; diabetes pre ... See more keywords

Two weeks of high‐fat feeding disturb lipid and cholesterol molecular markers

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recommendations! Published in 2018 at "Cell Biochemistry and Function"

DOI: 10.1002/cbf.3358

Abstract: Metabolic disorders are often associated with liver steatosis and increased plasma cholesterol levels. However, the link between excessive lipid accumulation and impairments in cholesterol metabolism remains uninvestigated in the liver. Short term of high‐fat diet… read more here.

Keywords: hfd; cholesterol metabolism; cholesterol; involved cholesterol ... See more keywords
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Combination of metformin and berberine represses the apoptosis of sebocytes in high‐fat diet‐induced diabetic hamsters and an insulin‐treated human cell line

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recommendations! Published in 2020 at "Cell Biochemistry and Function"

DOI: 10.1002/cbf.3504

Abstract: Obesity and insulin resistance affect metabolic reactions, but their ensuing contributions to macrophage metabolism remain insufficiently understood. We investigated the contributions of berberine and metformin combination to the inhibition of sebocyte apoptosis in high‐fat diet‐induced… read more here.

Keywords: fat diet; combination; apoptosis; diabetic hamsters ... See more keywords

Elucidation of the changes occurring at the proteome level in ovaries of high‐fat diet‐induced obese rats

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recommendations! Published in 2022 at "Cell Biochemistry and Function"

DOI: 10.1002/cbf.3693

Abstract: High‐fat diet‐induced obesity adversely affects the female reproductive system. The metabolic changes that the high‐fat diet causes on the ovaries have not been elucidated. Herein, to understand the molecular and cellular mechanisms underlying the effects… read more here.

Keywords: elucidation changes; proteins involved; high fat; diet induced ... See more keywords

Microbial creation of β‐Nicotinamide mononucleotide and its regulation of lipid metabolism in the liver of high‐fat diet mice

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recommendations! Published in 2024 at "Cell Biochemistry and Function"

DOI: 10.1002/cbf.4087

Abstract: β‐Nicotinamide mononucleotide (NMN) is a biologically active nucleotide that regulates the physiological metabolism of the body by rapidly increasing nicotinamide adenine dinucleotide (NAD+). To determine the safety and biological activity of NMN resources, we constructed… read more here.

Keywords: nicotinamide mononucleotide; lipid metabolism; fat diet; metabolism ... See more keywords

Effect of a High‐Fat Meal on Single‐Dose Rencofilstat (CRV431) Oral Bioavailability in Healthy Human Subjects

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recommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.1179

Abstract: Rencofilstat (RCF) is a novel cyclophilin inhibitor under development for the treatment of nonalcoholic steatohepatitis and hepatocellular carcinoma. This phase 1, randomized, open‐label study in healthy participants assessed the relative bioavailability of a single dose… read more here.

Keywords: single dose; fat meal; high fat; bioavailability ... See more keywords