Loss of EGFR contributes to high-fat diet-induced nonalcoholic fatty liver disease.
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DOI: 10.1002/1873-3468.14636
Abstract: Using a murine model of high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD), we found that the expression of the epidermal growth factor receptor (EGFR) significantly decreased in hepatocytes. In vitro, free fatty acid influx… read more here.
Keywords: fatty liver; high fat; egfr; liver disease ... See more keywords
Effects of high‐fat diet‐induced adipokines and cytokines on colorectal cancer development
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DOI: 10.1002/2211-5463.12751
Abstract: Colorectal cancer (CRC) is the third most common tumor worldwide, and recent epidemiological studies have indicated that obesity contributes to the morbidity and mortality of CRC. Furthermore, obesity‐related adipokines have been shown to be closely… read more here.
Keywords: fat diet; diet induced; adipokines cytokines; induced adipokines ... See more keywords
The effects of high-fat diet and metformin on urinary metabolites in diabetes and pre-diabetes rat models.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2021
Abstract: High-fat diet (HFD) interferes with the dietary plan of patients with type 2 diabetes mellitus (T2DM). However, many diabetes patients consume food with higher fat content for a better taste bud experience. In this study,… read more here.
Keywords: fat diet; pre diabetes; hfd; diabetes pre ... See more keywords
Two weeks of high‐fat feeding disturb lipid and cholesterol molecular markers
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DOI: 10.1002/cbf.3358
Abstract: Metabolic disorders are often associated with liver steatosis and increased plasma cholesterol levels. However, the link between excessive lipid accumulation and impairments in cholesterol metabolism remains uninvestigated in the liver. Short term of high‐fat diet… read more here.
Keywords: hfd; cholesterol metabolism; cholesterol; involved cholesterol ... See more keywords
Combination of metformin and berberine represses the apoptosis of sebocytes in high‐fat diet‐induced diabetic hamsters and an insulin‐treated human cell line
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3504
Abstract: Obesity and insulin resistance affect metabolic reactions, but their ensuing contributions to macrophage metabolism remain insufficiently understood. We investigated the contributions of berberine and metformin combination to the inhibition of sebocyte apoptosis in high‐fat diet‐induced… read more here.
Keywords: fat diet; combination; apoptosis; diabetic hamsters ... See more keywords
Elucidation of the changes occurring at the proteome level in ovaries of high‐fat diet‐induced obese rats
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3693
Abstract: High‐fat diet‐induced obesity adversely affects the female reproductive system. The metabolic changes that the high‐fat diet causes on the ovaries have not been elucidated. Herein, to understand the molecular and cellular mechanisms underlying the effects… read more here.
Keywords: elucidation changes; proteins involved; high fat; diet induced ... See more keywords
Effect of a High‐Fat Meal on Single‐Dose Rencofilstat (CRV431) Oral Bioavailability in Healthy Human Subjects
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DOI: 10.1002/cpdd.1179
Abstract: Rencofilstat (RCF) is a novel cyclophilin inhibitor under development for the treatment of nonalcoholic steatohepatitis and hepatocellular carcinoma. This phase 1, randomized, open‐label study in healthy participants assessed the relative bioavailability of a single dose… read more here.
Keywords: single dose; fat meal; high fat; bioavailability ... See more keywords
High-fat diet promotes prostate cancer growth through histamine signaling.
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DOI: 10.1002/ijc.34028
Abstract: Western high-fat diets (HFD) are regarded as a major risk factor for prostate cancer (PCa). Using prostate-specific Pten-knockout mice as a PCa model, we previously reported that HFD promoted inflammatory PCa growth. The composition of… read more here.
Keywords: growth; high fat; cancer; prostate cancer ... See more keywords
Nicotinamide mononucleotide alters body composition and ameliorates metabolic disorders induced by a high‐fat diet
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DOI: 10.1002/iub.2707
Abstract: Obesity is caused by an imbalance between calorie intake and energy expenditure, leading to excessive adipose tissue accumulation. Nicotinamide adenine dinucleotide (NAD+) is an important molecule in energy and signal transduction, and NAD+ supplementation therapy… read more here.
Keywords: nicotinamide mononucleotide; body composition; high fat; obesity ... See more keywords
The effects of boron‐supplemented diets on adipogenesis‐related gene expressions, anti‐inflammatory, and antioxidative response in high‐fat fed rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23257
Abstract: The fatty liver syndrome caused by nutritional factors is a common cause of hepatic dysfunction globally. This research was designed to study the shielding effect of boron in rats fed a diet having high fat.… read more here.
Keywords: fed rats; fat; fat fed; high fat ... See more keywords
Camellia nitidissima Chi flower extract alleviates obesity and related complications and modulates gut microbiota composition in rats with high-fat-diet-induced obesity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.10471
Abstract: BACKGROUND The aim of this study was to investigate the potential anti-obesity effects of Camellia nitidissima Chi flower extract (Cnfe) by examining its effects in terms of the regulation of lipid levels and modulation of… read more here.
Keywords: fat diet; rats high; diet induced; high fat ... See more keywords