Processing-Challenges Generated by Clusters of DNA Double-Strand Breaks Underpin Increased Effectiveness of High-LET Radiation and Chromothripsis.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-0593-1_10
Abstract: Whereas most endogenous and exogenous DNA damaging agents typically generate lesions that are relatively isolated and can be repaired easily, ionizing radiation (IR) also induces clustered lesions causing DNA double strand breaks (DSBs). Moreover, forms… read more here.
Keywords: dsb clusters; processing; chromothripsis; high let ... See more keywords
Palmitoyl ascorbic acid 2-glucoside has the potential to protect mammalian cells from high-LET carbon-ion radiation
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DOI: 10.1038/s41598-018-31747-1
Abstract: DMSO, glycerol, and ascorbic acid (AA) are used in pharmaceuticals and known to display radioprotective effects. The present study investigates radioprotective properties of novel glyceryl glucoside, ascorbic acid 2-glucoside, glyceryl ascorbate, and palmitoyl ascorbic acid… read more here.
Keywords: glucoside; carbon; ascorbic acid; let carbon ... See more keywords
Low and High LET Degradation Studies of Metal-Loaded Organic Phase Ligands in the ALSEP Process
Sign Up to like & getrecommendations! Published in 2023 at "Solvent Extraction and Ion Exchange"
DOI: 10.1080/07366299.2023.2202224
Abstract: ABSTRACT Organic solutions comprising the Actinide Lanthanide Separation Process (ALSEP) solvent consisting of 0.5 M 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester (HEH[EHP]) and 0.05 M N,N,N’,N’-tetra(2-ethylhexyl)diglycolamide (T2EHDGA) in n-dodecane were subjected to low LET and high LET irradiation… read more here.
Keywords: irradiation; loaded organic; heh ehp; degradation ... See more keywords
DNA polymerase θ-mediated repair of high LET radiation-induced complex DNA double-strand breaks
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad076
Abstract: Abstract DNA polymerase θ (POLQ) is a unique DNA polymerase that is able to perform microhomology-mediated end-joining as well as translesion synthesis (TLS) across an abasic (AP) site and thymine glycol (Tg). However, the biological… read more here.
Keywords: dna polymerase; dna; let; let radiation ... See more keywords
3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation
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DOI: 10.18632/oncotarget.22679
Abstract: DNA double-strand breaks (DSBs) induced by ionising radiation are considered the major cause of genotoxic mutations and cell death. While DSBs are dispersed throughout chromatin after X-rays or γ-irradiation, multiple types of DNA damage including… read more here.
Keywords: h2ax foci; dna; microscopy; formation ... See more keywords
DNA Damage Clustering after Ionizing Radiation and Consequences in the Processing of Chromatin Breaks
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DOI: 10.3390/molecules27051540
Abstract: Charged-particle radiotherapy (CPRT) utilizing low and high linear energy transfer (low-/high-LET) ionizing radiation (IR) is a promising cancer treatment modality having unique physical energy deposition properties. CPRT enables focused delivery of a desired dose to… read more here.
Keywords: ionizing radiation; dna damage; let; high let ... See more keywords