Processing-Challenges Generated by Clusters of DNA Double-Strand Breaks Underpin Increased Effectiveness of High-LET Radiation and Chromothripsis.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-0593-1_10
Abstract: Whereas most endogenous and exogenous DNA damaging agents typically generate lesions that are relatively isolated and can be repaired easily, ionizing radiation (IR) also induces clustered lesions causing DNA double strand breaks (DSBs). Moreover, forms… read more here.
Keywords: dsb clusters; processing; chromothripsis; high let ... See more keywords
A perspective on tumor radiation resistance following high-LET radiation treatment
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DOI: 10.1007/s00432-024-05757-8
Abstract: High-linear energy transfer (LET) radiation is a promising alternative to conventional low-LET radiation for therapeutic gain against cancer owing to its ability to induce complex and clustered DNA lesions. However, the development of radiation resistance… read more here.
Keywords: let radiation; radiation resistance; radiation; high let ... See more keywords
Palmitoyl ascorbic acid 2-glucoside has the potential to protect mammalian cells from high-LET carbon-ion radiation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31747-1
Abstract: DMSO, glycerol, and ascorbic acid (AA) are used in pharmaceuticals and known to display radioprotective effects. The present study investigates radioprotective properties of novel glyceryl glucoside, ascorbic acid 2-glucoside, glyceryl ascorbate, and palmitoyl ascorbic acid… read more here.
Keywords: glucoside; carbon; ascorbic acid; let carbon ... See more keywords
CRISPR/Cas9 generated DSB clusters mimic complex lesions induced by high-LET radiation and shift repair from c-NHEJ to mutagenic repair pathways
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DOI: 10.1038/s41598-025-22945-9
Abstract: DNA double-strand break (DSB) clusters are a hallmark of high-linear energy transfer (high-LET) radiation and are associated with pronounced biological effects, including reduced cell survival and elevated genomic instability. Our previous work in Chinese hamster… read more here.
Keywords: let radiation; repair; cell; high let ... See more keywords
Low and High LET Degradation Studies of Metal-Loaded Organic Phase Ligands in the ALSEP Process
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DOI: 10.1080/07366299.2023.2202224
Abstract: ABSTRACT Organic solutions comprising the Actinide Lanthanide Separation Process (ALSEP) solvent consisting of 0.5 M 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester (HEH[EHP]) and 0.05 M N,N,N’,N’-tetra(2-ethylhexyl)diglycolamide (T2EHDGA) in n-dodecane were subjected to low LET and high LET irradiation… read more here.
Keywords: irradiation; loaded organic; heh ehp; degradation ... See more keywords
DNA polymerase θ-mediated repair of high LET radiation-induced complex DNA double-strand breaks
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DOI: 10.1093/nar/gkad076
Abstract: Abstract DNA polymerase θ (POLQ) is a unique DNA polymerase that is able to perform microhomology-mediated end-joining as well as translesion synthesis (TLS) across an abasic (AP) site and thymine glycol (Tg). However, the biological… read more here.
Keywords: dna polymerase; dna; let; let radiation ... See more keywords
LET Dependence of 8-Hydroxy-2′-deoxyguanosine (8-OHdG) Generation in Mammalian Cells under Air-Saturated and Hypoxic Conditions: A Possible Experimental Approach to the Mechanism of the Decreasing Oxygen Effect in the High-LET Region
Sign Up to like & getrecommendations! Published in 2024 at "Radiation Research"
DOI: 10.1667/rade-23-00046.1
Abstract: One of the most distinguished features in biological effects of heavy ions would be the decrease of oxygen effect in the high-LET region. This feature has been referred to as the radiobiological basis for the… read more here.
Keywords: oxygen; oxygen effect; let region; high let ... See more keywords
Impact of Oxygen on DNA Damage Distribution in 3D Genome and its Correlation to Oxygen Enhancement Ratio after High-LET Irradiation.
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DOI: 10.1667/rade-25-00093.1
Abstract: The variation of the oxygen enhancement ratio (OER) across linear energy transfer (LET) currently lacks a comprehensive mechanistic interpretation and a mechanistic model. Our earlier research revealed a significant correlation between the distribution of double-strand… read more here.
Keywords: enhancement ratio; distribution; oxygen; high let ... See more keywords
3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation
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DOI: 10.18632/oncotarget.22679
Abstract: DNA double-strand breaks (DSBs) induced by ionising radiation are considered the major cause of genotoxic mutations and cell death. While DSBs are dispersed throughout chromatin after X-rays or γ-irradiation, multiple types of DNA damage including… read more here.
Keywords: h2ax foci; dna; microscopy; formation ... See more keywords
DNA Damage Clustering after Ionizing Radiation and Consequences in the Processing of Chromatin Breaks
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DOI: 10.3390/molecules27051540
Abstract: Charged-particle radiotherapy (CPRT) utilizing low and high linear energy transfer (low-/high-LET) ionizing radiation (IR) is a promising cancer treatment modality having unique physical energy deposition properties. CPRT enables focused delivery of a desired dose to… read more here.
Keywords: ionizing radiation; dna damage; let; high let ... See more keywords