The High Mutational Sensitivity of ccdA Antitoxin Is Linked to Codon Optimality
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac187
Abstract: Deep mutational scanning studies suggest that synonymous mutations are typically silent and that most exposed, non active-site residues are tolerant to mutations. Here we show that the ccdA antitoxin component of the E.coli ccdAB toxin-antitoxin… read more here.
Keywords: mutational sensitivity; ccda antitoxin; high mutational; antitoxin ... See more keywords
Pembrolizumab for metastatic adrenocortical carcinoma with high mutational burden
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DOI: 10.1097/md.0000000000013517
Abstract: Rationale: In the setting of metastatic or locally advanced adrenocortical carcinoma, a limited number of therapies are available and their efficacy is generally below modest. The backbone of treatment remains surgery, even for metastatic disease,… read more here.
Keywords: adrenocortical carcinoma; metastatic adrenocortical; mutational burden; high mutational ... See more keywords
High mutational load gets a response
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.364.6439.447-i
Abstract: Cancer Cancers harbor many genetic mutations. Defects in DNA mismatch repair prevent tumors from repairing certain types of DNA damage and lead to a hypermutable genomic state known as microsatellite instability (MSI). Some tumors with… read more here.
Keywords: science; high mutational; response; load gets ... See more keywords