Unbiased Metabolic Profiling Predicts Sensitivity of High MYC-Expressing Atypical Teratoid/Rhabdoid Tumors to Glutamine Inhibition with 6-Diazo-5-Oxo-L-Norleucine
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-0189
Abstract: Purpose: Atypical teratoid/rhabdoid tumors (AT/RT) are aggressive infantile brain tumors with poor survival. Recent advancements have highlighted significant molecular heterogeneity in AT/RT with an aggressive subgroup featuring overexpression of the MYC proto-oncogene. We perform the… read more here.
Keywords: metabolic profiling; unbiased metabolic; cell; myc ... See more keywords
Abstract 1381: Targeting histone acetyltransferases to reprogram high C-MYC expressing cancers
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1381
Abstract: In cancer, epigenetic modifications are strongly altered and are responsible for gene expression aberrations. In a drug screening initiative, we recently reported that proscillaridin, a cardiac glycoside (CG), exhibits unsuspected epigenetic and anticancer activities. To… read more here.
Keywords: high myc; myc expressing; histone; cancer ... See more keywords
High-MYC Cells Depend on NUAK1 to Prevent Stalled Transcription.
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DOI: 10.1158/2159-8290.cd-rw2020-022
Abstract: NUAK1 inhibition caused buildup of nonproductive stalled transcription complexes in high-MYC cells. read more here.
Keywords: high myc; stalled transcription; myc cells; cells depend ... See more keywords
Diffuse large B-cell lymphoma with concurrent high MYC and BCL2 expression shows evidence of active B-cell receptor signaling by quantitative immunofluorescence
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DOI: 10.1371/journal.pone.0172364
Abstract: B-cell receptor (BCR)-mediated signaling plays an important role in the pathogenesis of a subset of diffuse large B-cell lymphoma (DLBCL), and novel agents targeting this pathway are now in clinical use. We have previously identified… read more here.
Keywords: bcr; high myc; myc bcl2; expression ... See more keywords