High phosphate-induced downregulation of PPARγ contributes to CKD-associated vascular calcification.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2017.11.021
Abstract: Medial arterial calcification associated with hyperphosphatemia is a main cause of cardiovascular mortality in patients with chronic kidney disease (CKD), but the mechanisms underlying high phosphate-induced vascular calcification remain largely unknown. Here, we observed a… read more here.
Keywords: high phosphate; ppar; vascular calcification; calcification ... See more keywords
Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway
Sign Up to like & getrecommendations! Published in 2017 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfw252
Abstract: Abstract Background Hyperphosphataemia is an independent risk factor for accelerated cardiovascular disease in chronic kidney disease (CKD), although the mechanism for this is poorly understood. We investigated the effects of sustained exposure to a high-phosphate… read more here.
Keywords: high phosphate; endothelial function; effects phosphate; nitric oxide ... See more keywords
High‐phosphate diet causes atrial remodeling and increases atrial fibrillation vulnerability via STAT3/NF‐κB signaling and oxidative stress
Sign Up to like & getrecommendations! Published in 2023 at "Acta Physiologica"
DOI: 10.1111/apha.13964
Abstract: Hyperphosphatemia is associated with adverse cardiovascular outcomes in both the general population and patients with end‐stage renal disease. We evaluated whether high inorganic phosphate (Pi) intake causes atrial remodeling and increased atrial fibrillation (AF) risk. read more here.
Keywords: causes atrial; atrial fibrillation; high phosphate; atrial remodeling ... See more keywords
Cardiorenal Effects of Chronic High Phosphate Diet in Female Rats
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.2614
Abstract: Cardiorenal Syndrome Type 4 (CRS4) refers to the development of cardiovascular dysfunction as a result of chronic kidney disease. The accumulation of circulating phosphate in the later stages of chronic kidney disease (CKD) has been… read more here.
Keywords: physiology; pathology; high phosphate; mir ... See more keywords
Abstract 4365476: The Klotho Protein Reduces Vascular Calcification via Suppressing GPX4-mediated Ferroptosis in Vascular Smooth Muscle Cells
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4365476
Abstract: Objectives: Chronic kidney disease (CKD) patients exhibit elevated cardiovascular risk linked to vascular calcification—pathological calcium-phosphate deposition impairing vascular compliance. Previous studies identified reduced α-Klotho expression in CKD, potentially exacerbating phosphate dyshomeostasis. Hyperphosphatemia promotes vascular calcification… read more here.
Keywords: ferroptosis; high phosphate; klotho; gpx4 ... See more keywords
Arterial Calcification Is Regulated Via an miR-204/DNMT3a Regulatory Circuit Both In Vitro and in Female Mice
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2018-00320
Abstract: Arterial calcification is a common cardiovascular disease that initiates from a process of osteoblastic differentiation of vascular smooth muscle cells (VSMCs). Accumulating evidence has demonstrated that microRNAs play an important role in regulating arterial calcification.… read more here.
Keywords: high phosphate; dnmt3a; calcification; mir 204 ... See more keywords
High phosphate intake induces bone loss in nephrectomized thalassemic mice
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0268732
Abstract: Although patients with either β-thalassemia or chronic kidney disease (CKD) clinically correlate with severe osteoporosis, the mechanism by which CKD exposed to high phosphate affects bone turnover has not been characterized in β-thalassemia. We aimed… read more here.
Keywords: bko mice; bone loss; high phosphate; mice ... See more keywords
High Phosphate and Low Protein Mediate Arterial and Cutaneous Vascular Calcification in CKD Mice.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.0000000875
Abstract: BACKGROUND Medial artery calcification and cutaneous arteriolar calcification are prevalent in patients with chronic kidney disease (CKD) and are strongly associated with increased morbidity and mortality. Current experimental CKD models, however, often fail to fully… read more here.
Keywords: ckd; phosphate low; medial artery; vascular calcification ... See more keywords
25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) induces ectopic calcification
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Biochemistry and Nutrition"
DOI: 10.3164/jcbn.22-16
Abstract: Vascular calcification is an important pathogenesis related to cardiovascular disease and high mortality rate in chronic kidney disease (CKD) patients. It has been well-known that hyperphosphatemia induces osteochondrogenic transition of vascular smooth muscle cells (VSMCs)… read more here.
Keywords: calcification; hydroxyvitamin hydroxylase; cyp27b1; high phosphate ... See more keywords
Daprodustat Accelerates High Phosphate-Induced Calcification Through the Activation of HIF-1 Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.798053
Abstract: Aims: Chronic kidney disease (CKD) is frequently associated with other chronic diseases including anemia. Daprodustat (DPD) is a prolyl hydroxylase inhibitor, a member of a family of those new generation drugs that increase erythropoiesis via… read more here.
Keywords: calcification; phosphate induced; high phosphate; hif ... See more keywords
Short-term artificial adaptation of Rhizoglomus irregulare to high phosphate levels and its implications for fungal-plant interactions: phenotypic and transcriptomic insights
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2024.1385245
Abstract: Arbuscular mycorrhizal fungi (AMF) play a crucial role in enhancing plant growth, but their use in agriculture is limited due to several constraints. Elevated soil phosphate levels resulting from fertilization practices strongly inhibit fungal development… read more here.
Keywords: phosphate levels; plant; high phosphate; rhizoglomus irregulare ... See more keywords