High phosphate-induced downregulation of PPARγ contributes to CKD-associated vascular calcification.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2017.11.021
Abstract: Medial arterial calcification associated with hyperphosphatemia is a main cause of cardiovascular mortality in patients with chronic kidney disease (CKD), but the mechanisms underlying high phosphate-induced vascular calcification remain largely unknown. Here, we observed a… read more here.
Keywords: high phosphate; ppar; vascular calcification; calcification ... See more keywords
Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway
Sign Up to like & getrecommendations! Published in 2017 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfw252
Abstract: Abstract Background Hyperphosphataemia is an independent risk factor for accelerated cardiovascular disease in chronic kidney disease (CKD), although the mechanism for this is poorly understood. We investigated the effects of sustained exposure to a high-phosphate… read more here.
Keywords: high phosphate; endothelial function; effects phosphate; nitric oxide ... See more keywords
High‐phosphate diet causes atrial remodeling and increases atrial fibrillation vulnerability via STAT3/NF‐κB signaling and oxidative stress
Sign Up to like & getrecommendations! Published in 2023 at "Acta Physiologica"
DOI: 10.1111/apha.13964
Abstract: Hyperphosphatemia is associated with adverse cardiovascular outcomes in both the general population and patients with end‐stage renal disease. We evaluated whether high inorganic phosphate (Pi) intake causes atrial remodeling and increased atrial fibrillation (AF) risk. read more here.
Keywords: causes atrial; atrial fibrillation; high phosphate; atrial remodeling ... See more keywords
Arterial Calcification Is Regulated Via an miR-204/DNMT3a Regulatory Circuit Both In Vitro and in Female Mice
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2018-00320
Abstract: Arterial calcification is a common cardiovascular disease that initiates from a process of osteoblastic differentiation of vascular smooth muscle cells (VSMCs). Accumulating evidence has demonstrated that microRNAs play an important role in regulating arterial calcification.… read more here.
Keywords: high phosphate; dnmt3a; calcification; mir 204 ... See more keywords
High phosphate intake induces bone loss in nephrectomized thalassemic mice
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0268732
Abstract: Although patients with either β-thalassemia or chronic kidney disease (CKD) clinically correlate with severe osteoporosis, the mechanism by which CKD exposed to high phosphate affects bone turnover has not been characterized in β-thalassemia. We aimed… read more here.
Keywords: bko mice; bone loss; high phosphate; mice ... See more keywords
25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) induces ectopic calcification
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Biochemistry and Nutrition"
DOI: 10.3164/jcbn.22-16
Abstract: Vascular calcification is an important pathogenesis related to cardiovascular disease and high mortality rate in chronic kidney disease (CKD) patients. It has been well-known that hyperphosphatemia induces osteochondrogenic transition of vascular smooth muscle cells (VSMCs)… read more here.
Keywords: calcification; hydroxyvitamin hydroxylase; cyp27b1; high phosphate ... See more keywords
Daprodustat Accelerates High Phosphate-Induced Calcification Through the Activation of HIF-1 Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.798053
Abstract: Aims: Chronic kidney disease (CKD) is frequently associated with other chronic diseases including anemia. Daprodustat (DPD) is a prolyl hydroxylase inhibitor, a member of a family of those new generation drugs that increase erythropoiesis via… read more here.
Keywords: calcification; phosphate induced; high phosphate; hif ... See more keywords
Distinct Effects of High-Fat and High-Phosphate Diet on Glucose Metabolism and the Response to Voluntary Exercise in Male Mice
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14061201
Abstract: The prevalence of metabolic diseases is rapidly increasing and a principal contributor to this is diet, including increased consumption of energy-rich foods and foods with added phosphates. Exercise is an effective therapeutic approach to combat… read more here.
Keywords: phosphate diet; mice; high phosphate; high fat ... See more keywords