High-plex imaging and cellular neighborhood spatial analysis reveals multiple immune escape and suppression patterns in diffuse large B-cell lymphoma
Sign Up to like & getrecommendations! Published in 2024 at "Leukemia"
DOI: 10.1038/s41375-024-02239-1
Abstract: TO THE EDITOR: A hallmark of hematological malignancies such as diffuse large B-cell lymphoma (DLBCL) is heterogeneity, with contribution from the tumor and its microenvironment. Application of next generation sequencing technology to patient tumor biopsies… read more here.
Keywords: plex imaging; high plex; cell lymphoma; tumor ... See more keywords
The Novodiag® Stool parasites assay, an innovative high-plex technique for fast detection of protozoa, helminths and microsporidia in stool samples: a retrospective and prospective study
Sign Up to like & getrecommendations! Published in 2022 at "Parasite"
DOI: 10.1051/parasite/2022026
Abstract: Objectives: We provide the first evaluation of the CE-IVD marked Novodiag® stool parasites assay (NVD), allowing rapid and high-plex detection of 26 distinct targets, encompassing protozoans, helminths and microsporidia in stool samples. Methods: A total… read more here.
Keywords: novodiag stool; stool parasites; detection; high plex ... See more keywords
Opportunities for High-plex Spatial Transcriptomics in Solid Organ Transplantation.
Sign Up to like & getrecommendations! Published in 2023 at "Transplantation"
DOI: 10.1097/tp.0000000000004587
Abstract: The last 5 y have seen the development and widespread adoption of high-plex spatial transcriptomic technology. This technique detects and quantifies mRNA transcripts in situ, meaning that transcriptomic signatures can be sampled from specific cells,… read more here.
Keywords: plex spatial; transplantation; high plex; transplantation opportunities ... See more keywords
Abstract 3434: Digital spatial profiling platform allows for spatially resolved, high-plex quantification of mRNA distribution and abundance on FFPE and fresh frozen tissue sections
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3434
Abstract: Characterization of spatial mRNA expression across multiple targets in a single tissue section has proven difficult to accomplish. To address this unmet need, we have developed a novel imaging platform, Digital Spatial Profiling (DSP), designed… read more here.
Keywords: ffpe fresh; high plex; fresh frozen; tissue ... See more keywords
Abstract 4617: A complete pipeline for high-plex spatial proteomic profiling and analysis on the cosmxtm spatial molecular imager and atomtm spatial informatics platform
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4617
Abstract: Detecting and analyzing large numbers of proteins using whole-slide imaging is critical for a comprehensive picture of immune response to cancer. Many existing approaches for high-plex proteomics face issues around simplicity, speed, scalability, and big… read more here.
Keywords: oncology; analysis; high plex; spatial molecular ... See more keywords
Abstract 2089: Spatial profiling of exhausted T cells using high-plex imaging mass cytometry
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-2089
Abstract: The spatial organization and cellular composition of the tumor microenvironment (TME) has the potential to inform clinical and translational researchers about mechanisms of disease progression and therapeutic success. Of particular interest are immune cells, especially… read more here.
Keywords: cancer; exhausted cells; high plex; biology ... See more keywords
Abstract B124: Rapid, high-plex spatial proteomic profiling of pancreatic cancer using a pancreas-focused-assay and customized analysis workflow
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.pancreatic25-b124
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is currently the 3rd leading cause of cancer-related deaths in the United States. While studying tissue from human patients holds promise for developing new therapies, this approach is challenging due to… read more here.
Keywords: cancer; plex spatial; high plex; cell ... See more keywords
Challenges and Opportunities for Immunoprofiling Using a Spatial High-Plex Technology: The NanoString GeoMx® Digital Spatial Profiler
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.890410
Abstract: Characterization of the tumor microenvironment through immunoprofiling has become an essential resource for the understanding of the complex immune cell interactions and the assessment of biomarkers for prognosis and prediction of immunotherapy response; however, these… read more here.
Keywords: oncology; plex; technology; nanostring geomx ... See more keywords