High prevalence of unusual KRAS, NRAS, and BRAF mutations in POLE ‐ hypermutated colorectal cancers
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13257
Abstract: Exonucleasic domain POLE (edPOLE) mutations, which are responsible for a hypermutated tumor phenotype, occur in 1–2% of colorectal cancer (CRC) cases. These alterations represent an emerging biomarker for response to immune checkpoint blockade. This study… read more here.
Keywords: edpole mutations; edpole mutated; high prevalence; prevalence ... See more keywords
High prevalence of epilepsy in Northern Rwanda: Exploring gender differences.
Sign Up to like & getrecommendations! Published in 2021 at "Brain and behavior"
DOI: 10.1002/brb3.2377
Abstract: INTRODUCTION In sub-Saharan Africa (SSA), the prevalence of lifetime epilepsy varies widely between subregions and is higher in rural compared to urban regions. Observed versus expected numbers of patients with epilepsy (PwE) in the northern… read more here.
Keywords: epilepsy; gender differences; high prevalence; prevalence ... See more keywords
High prevalence of diabetes‐specific autoimmunity in first‐degree relatives of Sardinian patients with type 1 diabetes
Sign Up to like & getrecommendations! Published in 2017 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.2864
Abstract: The incidence of type 1 diabetes mellitus (T1DM) in Sardinia is among the highest in the world (44.8 cases/100,000 person‐years). Recommendations of the Immunology of Diabetes Society advise evaluating autoantibody positivity in first‐degree relatives (FDRs)… read more here.
Keywords: degree relatives; first degree; high prevalence; type diabetes ... See more keywords
High prevalence of cancer‐associated TP53 variants in the gnomAD database: A word of caution concerning the use of variant filtering
Sign Up to like & getrecommendations! Published in 2019 at "Human Mutation"
DOI: 10.1002/humu.23717
Abstract: The 1,000 genome project, the Exome Aggregation Consortium (ExAC) or the Genome Aggregation database (gnomAD) datasets, were developed to provide large‐scale reference data of genetic variations for various populations to filter out common benign variants… read more here.
Keywords: tp53 variants; caution; high prevalence; prevalence cancer ... See more keywords
Screening endoscopy finds high prevalence of Helicobacter pylori and intestinal metaplasia in Korean American with limited access to health care
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.24622
Abstract: Gastric cancer (GC) is the leading cause of cancer death among Korean Americans. Prevention and early detection is improved by screening. read more here.
Keywords: endoscopy finds; high prevalence; screening endoscopy; finds high ... See more keywords
High prevalence of bla CTX‐M‐15 type extended‐spectrum beta‐lactamases in Gambian hooded vultures (Necrosyrtes monachus): A threatened species with substantial human interaction
Sign Up to like & getrecommendations! Published in 2023 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.1349
Abstract: One hundred fecal samples from hooded vultures in the Gambia (Banjul area) were investigated for the presence of bacteria with extended‐spectrum cephalosporin‐ (ESBL/AmpC), carbapenemases, and colistin resistance. No Enterobacteriales carrying carbapenemases or resistance against colistin… read more here.
Keywords: high prevalence; esbl; resistance; hooded vultures ... See more keywords
Pseudodominance in Friedreich Ataxia—Impact of High Prevalence of Carriers and Intrafamilial Clinical Variation
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13694
Abstract: Friedreich ataxia (FA) is the most common form of autosomal recessive (AR) ataxia. It is a rare disease, but carriers are frequent (1/100). Pseudodominance in FA has seldomly been reported; it may pose additional challenges… read more here.
Keywords: high prevalence; impact high; friedreich ataxia; pseudodominance ... See more keywords
Prospective validation of an acoustic-based system for the detection of obstructive coronary artery disease in a high-prevalence population
Sign Up to like & getrecommendations! Published in 2021 at "Heart and Vessels"
DOI: 10.1007/s00380-021-01800-7
Abstract: Recent guidelines recommend a risk-adjusted, non-invasive work-up in patients presenting with chest discomfort to exclude coronary artery disease (CAD). However, a risk-adjusted diagnostic approach remains challenging in clinical practice. An acoustic detection device for analyzing… read more here.
Keywords: detection; high prevalence; cad; value ... See more keywords
High prevalence of human papillomavirus type 66 in low-grade cervical lesions of Mexican women
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Virology"
DOI: 10.1007/s00705-020-04771-8
Abstract: Our aim was to analyze the prevalence of high-risk human papillomavirus (HR-HPV) and its association with risk factors related to cervical lesions. We used 362 cervical samples from a transversal study to detect nineteen types… read more here.
Keywords: high prevalence; prevalence; human papillomavirus; low grade ... See more keywords
High prevalence of contamination of sink drains with carbapenemase-producing Enterobacteriaceae in 4 intensive care units apart from any epidemic context.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of infection control"
DOI: 10.1016/j.ajic.2019.08.007
Abstract: We report a high prevalence (28%) of sink drains contaminated with carbapenemase-producing Enterobacteriaceae (CPE) in 4 intensive care units with a history of CPE carriage in hospitalized patients within the previous 5 years, but apart… read more here.
Keywords: carbapenemase producing; high prevalence; producing enterobacteriaceae; sink ... See more keywords
Anthropometric parameters and permanent remission of comorbidities 10 years after open gastric bypass in a cohort with high prevalence of super-obesity.
Sign Up to like & getrecommendations! Published in 2017 at "Endocrinologia, diabetes y nutricion"
DOI: 10.1016/j.endinu.2017.03.013
Abstract: BACKGROUND AND AIM Roux-en-Y gastric bypass (RYGB) is an effective treatment for weight loss in patients with morbid obesity. However, few studies have assessed its long-term efficacy in super-obese patients. The study objective was to… read more here.
Keywords: bypass; gastric bypass; high prevalence; comorbidities years ... See more keywords