A superparamagnetic polymersome with extremely high T2 relaxivity for MRI and cancer-targeted drug delivery.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2016.10.027
Abstract: Improving the relaxivity of magnetic resonance imaging (MRI) contrast agents is an important challenge for cancer theranostics. Herein we report the design, synthesis, characterization, theoretical analysis and in vivo tests of a superparamagnetic polymersome as a… read more here.
Keywords: high relaxivity; superparamagnetic polymersome; mri; extremely high ... See more keywords
High Relaxivity with No Coordinated Waters: A Seemingly Paradoxical Behavior of [Gd(DOTP)]5- Embedded in Nanogels.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c00225
Abstract: Nanogels (NGs) obtained by electrostatic interactions between chitosan and hyaluronic acid and comprising paramagnetic Gd chelates are gaining increasing attention for their potential application in magnetic resonance bioimaging. Herein, the macrocyclic complexes [Gd(DOTP)]5-, lacking metal-bound… read more here.
Keywords: relaxivity; relaxivity coordinated; high relaxivity; waters seemingly ... See more keywords
Physicochemical and Pharmacokinetic Profiles of Gadopiclenol
Sign Up to like & getrecommendations! Published in 2019 at "Investigative Radiology"
DOI: 10.1097/rli.0000000000000563
Abstract: Abstract Objectives We aimed to evaluate gadopiclenol, a newly developed extracellular nonspecific macrocyclic gadolinium-based contrast agent (GBCA) having high relaxivity properties, which was designed to increase lesion detection and characterization by magnetic resonance imaging. Methods… read more here.
Keywords: protein binding; relaxivity; profile; gadopiclenol ... See more keywords