Early administration of COVID‐19 convalescent plasma with high titer antibody content by live viral neutralization assay is associated with modest clinical efficacy
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26531
Abstract: The efficacy of COVID‐19 convalescent plasma (CCP) as a treatment for hospitalized patients with COVID‐19 remains somewhat controversial; however, many studies have not evaluated CCP documented to have high neutralizing antibody titer by a highly… read more here.
Keywords: neutralization assay; high titer; live viral; viral neutralization ... See more keywords
The Superiority of Sucrose Cushion Centrifugation to Ultrafiltration and PEGylation in Generating High-Titer Lentivirus Particles and Transducing Stem Cells with Enhanced Efficiency
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biotechnology"
DOI: 10.1007/s12033-017-0044-5
Abstract: Viral gene delivery is hailed as a great milestone in gene-based therapeutic approaches. The human immunodeficiency virus-derived lentiviral vectors (LVs) are advantageous in infecting both dividing and non-dividing cells leading to continuous expression of transgenes.… read more here.
Keywords: cushion centrifugation; sucrose cushion; lentivirus particles; high titer ... See more keywords
Assessment of High-Titer Convalescent Plasma as an Adjunctive Therapy in the Reduction of Mortality Rate and Viral Load in Patients with Severe COVID-19: A Meta-Analysis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2021.12.088
Abstract: Purpose COVID-19 has emerged as the "first pandemic of the 21st Century" and continues to pose challenges to global health. Currently, the most common symptomatic management of COVID-19 patients involves isolation and oxygen therapy. However,… read more here.
Keywords: high titer; analysis; mortality rate; therapy ... See more keywords
Cost of Patients With Hemophilia A and High-Titer Inhibitors in Colombia.
Sign Up to like & getrecommendations! Published in 2019 at "Value in health regional issues"
DOI: 10.1016/j.vhri.2019.08.473
Abstract: BACKGROUND In Colombia, hemophilia is considered a high-cost disease, and hemophilia A with high-titer inhibitors may be responsible for a significant economic pressure on the Colombian health system. OBJECTIVES To estimate the direct cost of… read more here.
Keywords: patients hemophilia; titer inhibitors; hemophilia high; high titer ... See more keywords
Engineering Escherichia coli for the High-Titer Biosynthesis of Lacto-N-tetraose.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02423
Abstract: Lacto-N-tetraose (LNT), a member of the human milk oligosaccharides family, has received widespread attention because of its importance in infant health. We constructed a whole-cell biotransformation method in Escherichia coli BL21(DE3) for high-titer LNT synthesis.… read more here.
Keywords: lnt; escherichia coli; high titer; titer ... See more keywords
Co-Immobilizing Two Glycosidases Based on Cross-Linked Enzyme Aggregates to Enhance Enzymatic Properties for Achieving High Titer Icaritin Biosynthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c04253
Abstract: Icaritin is a rare and high-value isopentane flavonoid compound with remarkable activities. Increasing yields while reducing cost has been a great challenge in icaritin production. Herein, we first reported a high titer icaritin biosynthesis strategy… read more here.
Keywords: cross linked; high titer; titer icaritin; linked enzyme ... See more keywords
Bacillus cereus isolated from a positive bone tissue culture in a patient with osteolysis and high-titer anti-interferon-γ autoantibodies
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000017609
Abstract: Abstract Rationale: Bacillus cereus (B cereus) is an aerobic or facultative anaerobic gram-positive, spore-forming bacterium. It can cause fatal disease and generally manifests as 3 distinct syndromes: food intoxication, localized infection, and systemic infection. It… read more here.
Keywords: titer; titer anti; infection; high titer ... See more keywords
Production of high‐titer transmission‐defective RNA virus‐based episomal vector using tangential flow filtration
Sign Up to like & getrecommendations! Published in 2020 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12831
Abstract: In recent years, viral vector based in vivo gene delivery strategies have achieved a significant success in the treatment of genetic diseases. RNA virus‐based episomal vector lacking viral glycoprotein gene (ΔG‐REVec) is a nontransmissive gene… read more here.
Keywords: vector; virus based; high titer; gene ... See more keywords
Multi‐level metabolic engineering of Escherichia coli for high‐titer biosynthesis of 2′‐fucosyllactose and 3‐fucosyllactose
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DOI: 10.1111/1751-7915.14152
Abstract: Fucosyllactoses (FL), including 2′‐fucosyllactose (2′‐FL) and 3‐fucosyllactose (3‐FL), have garnered considerable interest for their value in newborn formula and pharmaceuticals. In this study, an engineered Escherichia coli was developed for high‐titer FL biosynthesis by introducing… read more here.
Keywords: titer biosynthesis; biosynthesis; escherichia coli; high titer ... See more keywords
High‐titer convalescent plasma therapy for coronavirus disease 2019 and mortality
Sign Up to like & getrecommendations! Published in 2021 at "Transfusion"
DOI: 10.1111/trf.16434
Abstract: One of the limited number of choices for the treatment of coronavirus disease 2019 (COVID-19) is to administer plasma, containing neutralizing anti-viral antibodies, from donors who have recovered from the disease. This so-called convalescent plasma… read more here.
Keywords: plasma; treatment; disease; mortality ... See more keywords
Efficacy of early transfusion of convalescent plasma with high‐titer SARS‐CoV‐2 neutralizing antibodies in hospitalized patients with COVID‐19
Sign Up to like & getrecommendations! Published in 2022 at "Transfusion"
DOI: 10.1111/trf.16863
Abstract: Despite most controlled trials have shown no measurable benefit of COVID‐19 convalescent plasma (CCP) in patients with COVID‐19, some studies suggest that early administration of CCP with high‐titer anti‐SARS‐CoV‐2 can be beneficial in selected patients.… read more here.
Keywords: high titer; efficacy early; patients covid; convalescent plasma ... See more keywords