Early administration of COVID‐19 convalescent plasma with high titer antibody content by live viral neutralization assay is associated with modest clinical efficacy
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26531
Abstract: The efficacy of COVID‐19 convalescent plasma (CCP) as a treatment for hospitalized patients with COVID‐19 remains somewhat controversial; however, many studies have not evaluated CCP documented to have high neutralizing antibody titer by a highly… read more here.
Keywords: neutralization assay; high titer; live viral; viral neutralization ... See more keywords
The Superiority of Sucrose Cushion Centrifugation to Ultrafiltration and PEGylation in Generating High-Titer Lentivirus Particles and Transducing Stem Cells with Enhanced Efficiency
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biotechnology"
DOI: 10.1007/s12033-017-0044-5
Abstract: Viral gene delivery is hailed as a great milestone in gene-based therapeutic approaches. The human immunodeficiency virus-derived lentiviral vectors (LVs) are advantageous in infecting both dividing and non-dividing cells leading to continuous expression of transgenes.… read more here.
Keywords: cushion centrifugation; sucrose cushion; lentivirus particles; high titer ... See more keywords
Assessment of High-Titer Convalescent Plasma as an Adjunctive Therapy in the Reduction of Mortality Rate and Viral Load in Patients with Severe COVID-19: A Meta-Analysis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2021.12.088
Abstract: Purpose COVID-19 has emerged as the "first pandemic of the 21st Century" and continues to pose challenges to global health. Currently, the most common symptomatic management of COVID-19 patients involves isolation and oxygen therapy. However,… read more here.
Keywords: high titer; analysis; mortality rate; therapy ... See more keywords
Cost of Patients With Hemophilia A and High-Titer Inhibitors in Colombia.
Sign Up to like & getrecommendations! Published in 2019 at "Value in health regional issues"
DOI: 10.1016/j.vhri.2019.08.473
Abstract: BACKGROUND In Colombia, hemophilia is considered a high-cost disease, and hemophilia A with high-titer inhibitors may be responsible for a significant economic pressure on the Colombian health system. OBJECTIVES To estimate the direct cost of… read more here.
Keywords: patients hemophilia; titer inhibitors; hemophilia high; high titer ... See more keywords
Engineering Escherichia coli for the High-Titer Biosynthesis of Lacto-N-tetraose.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02423
Abstract: Lacto-N-tetraose (LNT), a member of the human milk oligosaccharides family, has received widespread attention because of its importance in infant health. We constructed a whole-cell biotransformation method in Escherichia coli BL21(DE3) for high-titer LNT synthesis.… read more here.
Keywords: lnt; escherichia coli; high titer; titer ... See more keywords
Co-Immobilizing Two Glycosidases Based on Cross-Linked Enzyme Aggregates to Enhance Enzymatic Properties for Achieving High Titer Icaritin Biosynthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c04253
Abstract: Icaritin is a rare and high-value isopentane flavonoid compound with remarkable activities. Increasing yields while reducing cost has been a great challenge in icaritin production. Herein, we first reported a high titer icaritin biosynthesis strategy… read more here.
Keywords: cross linked; high titer; titer icaritin; linked enzyme ... See more keywords
Engineering Streptomyces albus B4 for Enhanced Production of (R)-Mellein: A High-Titer Heterologous Biosynthesis Approach.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c02463
Abstract: The natural compound (R)-(-)-mellein exhibits antiseptic and fungicidal activities. We investigated its biosynthesis using the polyketide synthase encoded by SACE_5532 (pks8) from Saccharopolyspora erythraea heterologously expressed in Streptomyces albus B4, a chassis chosen for its… read more here.
Keywords: high titer; biosynthesis; engineering streptomyces; streptomyces albus ... See more keywords
218. Attenuated PreFusion F Antibody Response to RSV Vaccines in Solid Organ Transplant Recipients
Sign Up to like & getrecommendations! Published in 2025 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofae631.076
Abstract: Abstract Background RSV causes serious morbidity in solid organ transplant recipients (SOTRs). Novel RSV vaccines are highly protective in the general population, yet immunogenicity among SOTRs is unknown. Demographic and Transplant Characteristics of SOTRs Reporting… read more here.
Keywords: titer; high titer; response; rsv ... See more keywords
Anti-muscarinic 3 antibodies associate with a severe clinical phenotype in patients with systemic sclerosis.
Sign Up to like & getrecommendations! Published in 2025 at "Rheumatology"
DOI: 10.1093/rheumatology/keaf197
Abstract: OBJECTIVES Functional antibodies play a role in SSc gastrointestinal (GI) disease, but their clinical relevance is unclear. We examined GI and extraintestinal features associated with anti-M3R antibodies in SSc patients. METHODS In a cohort enriched… read more here.
Keywords: severity; high titer; anti m3r; m3r antibodies ... See more keywords
Bacillus cereus isolated from a positive bone tissue culture in a patient with osteolysis and high-titer anti-interferon-γ autoantibodies
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000017609
Abstract: Abstract Rationale: Bacillus cereus (B cereus) is an aerobic or facultative anaerobic gram-positive, spore-forming bacterium. It can cause fatal disease and generally manifests as 3 distinct syndromes: food intoxication, localized infection, and systemic infection. It… read more here.
Keywords: titer; titer anti; infection; high titer ... See more keywords
Production of high‐titer transmission‐defective RNA virus‐based episomal vector using tangential flow filtration
Sign Up to like & getrecommendations! Published in 2020 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12831
Abstract: In recent years, viral vector based in vivo gene delivery strategies have achieved a significant success in the treatment of genetic diseases. RNA virus‐based episomal vector lacking viral glycoprotein gene (ΔG‐REVec) is a nontransmissive gene… read more here.
Keywords: vector; virus based; high titer; gene ... See more keywords