Development and validation of an MRI-based nomogram for the preoperative prediction of tumor mutational burden in lower-grade gliomas.
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DOI: 10.21037/qims-21-300
Abstract: Background High tumor mutational burden (TMB) is an emerging biomarker of sensitivity to immune checkpoint inhibitors. In this study, we aimed to determine the value of magnetic resonance (MR)-based preoperative nomogram in predicting TMB status… read more here.
Keywords: validation; tumor mutational; high tmb; mutational burden ... See more keywords
Urothelial Bladder Carcinomas with High Tumor Mutation Burden Have a Better Prognosis and Targetable Molecular Defects beyond Immunotherapies
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DOI: 10.3390/curroncol29030117
Abstract: Background: Urothelial bladder carcinomas had traditionally been difficult to treat cancers, with high morbidity and mortality rates when invasive and metastatic. In recent years, immunotherapy with immune checkpoint inhibitors has improved outcomes in several cancers,… read more here.
Keywords: carcinomas; high tmb; carcinomas high; tmb ... See more keywords