Surgical management for peritoneal carcinomatosis of appendiceal origin with a high-tumor burden
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DOI: 10.1007/s00595-019-01856-z
Abstract: Purpose Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) is the active treatment for peritoneal carcinomatosis of appendiceal origin. However, surgical management is sometimes difficult in patients with a high-tumor burden. Methods A high-tumor burden was… read more here.
Keywords: patients pci; high tumor; peritoneal carcinomatosis; tumor burden ... See more keywords
Double-endpoint Genotoxicity Quantification and PAHs Characterization of Drinking Water Source alongside Polluted Yinghe River with High Tumor Mortality
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DOI: 10.1007/s11596-021-2336-z
Abstract: The etiology for the high tumor mortality in heavy polluted Yinghe river basin is still unclear and polycyclic aromatic hydrocarbons (PAHs) belong to the priority pollutants in water based on the former surveillance data. In… read more here.
Keywords: tumor mortality; water; yinghe river; genotoxicity ... See more keywords
Unexpected favorable outcome to sintilimab monotherapy in a relapse pancreatic ductal adenocarcinoma patient with high tumor mutational burden: a case report
Sign Up to like & getrecommendations! Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001334
Abstract: The reason that immune checkpoint inhibitors have not been widely applied to pancreatic cancer treatment is probably because of low immunogenicity or dense stromal fibrosis. Recently, only pembrolizumab was recommended for DNA mismatch repair deficiency… read more here.
Keywords: sintilimab; ductal adenocarcinoma; report; monotherapy ... See more keywords
Prognostic significance of tumor budding in melanoma
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DOI: 10.1097/cmr.0000000000000839
Abstract: Cutaneous melanoma is an aggressive neoplasm with growing incidence and continuous research is undertaken for novel prognostic factors. This current research aims to determine if tumor budding is an independent factor that correlates with the… read more here.
Keywords: 785 mm2; tumor budding; high tumor; stage ... See more keywords
Complete remission after pembrolizumab monotherapy in a non-small cell lung cancer patient with PD-L1 negative, high tumor mutational burden, and positive tumor-infiltrating lymphocytes: A case report
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DOI: 10.1097/md.0000000000040369
Abstract: Rationale: Immune checkpoint inhibitors have been used to treat cancer patients. Non-small cell lung cancer (NSCLC) patients with a high expression level of programmed cell death ligand-1 (PD-L1) could benefit from immune checkpoint inhibitor monotherapy.… read more here.
Keywords: tumor mutational; lung; tumor; negative high ... See more keywords
Successful treatment with nivolumab for SMARCA4‐deficient non‐small cell lung carcinoma with a high tumor mutation burden: A case report
Sign Up to like & getrecommendations! Published in 2019 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.13070
Abstract: SMARCA4 is a subunit of the switch/sucrose non‐fermentable (SWI/SNF) chromatin‐remodeling complex. An effective treatment for SMARCA4‐deficient non‐small cell lung carcinoma (NSCLC) has not yet been established. Correlations between a response to immune checkpoint inhibitors and… read more here.
Keywords: tumor mutation; treatment; smarca4 deficient; high tumor ... See more keywords
Noninvasive Detection of Microsatellite Instability and High Tumor Mutation Burden in Cancer Patients Treated with PD-1 Blockade
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DOI: 10.1158/1078-0432.ccr-19-1372
Abstract: Purpose: Microsatellite instability (MSI) and high tumor mutation burden (TMB-High) are promising pan-tumor biomarkers used to select patients for treatment with immune checkpoint blockade; however, real-time sequencing of unresectable or metastatic solid tumors is often… read more here.
Keywords: tmb high; cancer; high tumor; microsatellite instability ... See more keywords
SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity
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DOI: 10.1158/2326-6066.cir-17-0051
Abstract: T cell–based immunotherapy against melanoma-associated antigens can result in on-target/off-tumor cytotoxicity. SLC45A2, a protein overexpressed in melanoma compared with normal melanocytes, was identified as a T-cell target that may be less prone to inducing autoimmune… read more here.
Keywords: melanoma; slc45a2; tumor selectivity; selectivity reduced ... See more keywords
Debulking Conventional Chemotherapy before Treatment By Anti-BCMA Bispecific Antibody in Extramedullary and/or High Tumor Burden Relapsed/Refractory Multiple Myeloma
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DOI: 10.1182/blood-2024-203778
Abstract: Background. New immunotherapies have improved response rates and survival in relapse/refractory multiple myeloma (RRMM) setting. However, patients with extramedullary disease (EMD) and/or high tumor burden continue to have poor response rates and inferior survival, representing… read more here.
Keywords: anti bcma; response; chemotherapy; tumor burden ... See more keywords
Hepatic arterial infusion chemotherapy plus lenvatinib and PD-1 inhibitors as first-line treatment for hepatocellular carcinoma with high tumor burden and portal vein tumor thrombus.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.4108
Abstract: 4108 Background: Advanced-stage hepatocellular carcinoma (HCC) is usually associated with poor survival outcomes. Rapid tumor control usually benefits long-term outcomes, which could be hardly achieved by solely systematic targeted and immunotherapy in current guidelines. This… read more here.
Keywords: treatment; first line; line treatment; tumor ... See more keywords
Fixed duration subcutaneous (SC) mosunetuzumab (Mosun) in patients with previously untreated high-tumor burden follicular lymphoma (FL): Interim results from the phase II MorningSun study.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.7014
Abstract: 7014 Background: Mosun is a CD20xCD3 bispecific antibody that can be administered in the outpatient setting for a fixed duration. Intravenous Mosun is approved for the treatment of relapsed/refractory FL after ≥2 prior lines of… read more here.
Keywords: untreated high; previously untreated; mosun; patients previously ... See more keywords