Surgical management for peritoneal carcinomatosis of appendiceal origin with a high-tumor burden
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DOI: 10.1007/s00595-019-01856-z
Abstract: Purpose Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) is the active treatment for peritoneal carcinomatosis of appendiceal origin. However, surgical management is sometimes difficult in patients with a high-tumor burden. Methods A high-tumor burden was… read more here.
Keywords: patients pci; high tumor; peritoneal carcinomatosis; tumor burden ... See more keywords
Double-endpoint Genotoxicity Quantification and PAHs Characterization of Drinking Water Source alongside Polluted Yinghe River with High Tumor Mortality
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DOI: 10.1007/s11596-021-2336-z
Abstract: The etiology for the high tumor mortality in heavy polluted Yinghe river basin is still unclear and polycyclic aromatic hydrocarbons (PAHs) belong to the priority pollutants in water based on the former surveillance data. In… read more here.
Keywords: tumor mortality; water; yinghe river; genotoxicity ... See more keywords
Unexpected favorable outcome to sintilimab monotherapy in a relapse pancreatic ductal adenocarcinoma patient with high tumor mutational burden: a case report
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DOI: 10.1097/cad.0000000000001334
Abstract: The reason that immune checkpoint inhibitors have not been widely applied to pancreatic cancer treatment is probably because of low immunogenicity or dense stromal fibrosis. Recently, only pembrolizumab was recommended for DNA mismatch repair deficiency… read more here.
Keywords: sintilimab; ductal adenocarcinoma; report; monotherapy ... See more keywords
Prognostic significance of tumor budding in melanoma
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DOI: 10.1097/cmr.0000000000000839
Abstract: Cutaneous melanoma is an aggressive neoplasm with growing incidence and continuous research is undertaken for novel prognostic factors. This current research aims to determine if tumor budding is an independent factor that correlates with the… read more here.
Keywords: 785 mm2; tumor budding; high tumor; stage ... See more keywords
Successful treatment with nivolumab for SMARCA4‐deficient non‐small cell lung carcinoma with a high tumor mutation burden: A case report
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DOI: 10.1111/1759-7714.13070
Abstract: SMARCA4 is a subunit of the switch/sucrose non‐fermentable (SWI/SNF) chromatin‐remodeling complex. An effective treatment for SMARCA4‐deficient non‐small cell lung carcinoma (NSCLC) has not yet been established. Correlations between a response to immune checkpoint inhibitors and… read more here.
Keywords: tumor mutation; treatment; smarca4 deficient; high tumor ... See more keywords
Noninvasive Detection of Microsatellite Instability and High Tumor Mutation Burden in Cancer Patients Treated with PD-1 Blockade
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DOI: 10.1158/1078-0432.ccr-19-1372
Abstract: Purpose: Microsatellite instability (MSI) and high tumor mutation burden (TMB-High) are promising pan-tumor biomarkers used to select patients for treatment with immune checkpoint blockade; however, real-time sequencing of unresectable or metastatic solid tumors is often… read more here.
Keywords: tmb high; cancer; high tumor; microsatellite instability ... See more keywords
SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity
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DOI: 10.1158/2326-6066.cir-17-0051
Abstract: T cell–based immunotherapy against melanoma-associated antigens can result in on-target/off-tumor cytotoxicity. SLC45A2, a protein overexpressed in melanoma compared with normal melanocytes, was identified as a T-cell target that may be less prone to inducing autoimmune… read more here.
Keywords: melanoma; slc45a2; tumor selectivity; selectivity reduced ... See more keywords
High Tumor Burden Predicts Poor Response to Enzalutamide in Metastatic Castration-Resistant Prostate Cancer Patients
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DOI: 10.3390/cancers13163966
Abstract: Simple Summary Several available medications are involved in the treatment of metastatic castration-resistant prostate cancer (mCRPC). In this Taiwanese mCRPC cohort receiving enzalutamide patients with high tumor burden (HTB) were defined as those with either… read more here.
Keywords: prostate; high tumor; response; tumor burden ... See more keywords
Peritoneal Seeding Is More Common in Gastric Cancer Patients with FGFR2 Amplification or High Tumor Mutation Burden
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DOI: 10.3390/diagnostics12102355
Abstract: Fibroblast growth factor receptor-2 (FGFR2) gene alterations have been identified in solid tumors. FGFR2 amplification is found in 2–9% of gastric carcinomas. We hypothesized that FGFR2 could be associated with peritoneal seeding and studied 360… read more here.
Keywords: patients fgfr2; peritoneal seeding; amplification; fgfr2 amplification ... See more keywords