High uric acid induced hippocampal mitochondrial dysfunction and cognitive impairment involving intramitochondrial NF-κB inhibitor α/nuclear factor-κB pathway
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DOI: 10.1097/wnr.0000000000001762
Abstract: Objectives Epidemiological research has indicated that hyperuricemia may impair cognitive ability; however, the underlying mechanisms remain unclear. The present study thus investigated the possible mechanism underlying hyperuricemia-related cognitive impairment. Methods Using hyperuricemic rats and high… read more here.
Keywords: inhibitor nuclear; high uric; cognitive impairment; hippocampal mitochondrial ... See more keywords
Metformin protects against insulin resistance induced by high uric acid in cardiomyocytes via AMPK signalling pathways in vitro and in vivo
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DOI: 10.1111/jcmm.16677
Abstract: High uric acid (HUA) is associated with insulin resistance (IR) in cardiomyocytes. We investigated whether metformin protects against HUA‐induced IR in cardiomyocytes. We exposed primary cardiomyocytes to HUA, and cellular glucose uptake was quantified by… read more here.
Keywords: uric acid; high uric; metformin; ampk ... See more keywords
High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy.
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DOI: 10.5551/jat.63645
Abstract: AIMS Acute rupture or erosion of unstable atherosclerotic plaques is a major cause of adverse consequences of atherosclerotic cardiovascular disease, often leading to myocardial infarction or stroke. High uric acid (HUA) is associated with the… read more here.
Keywords: apoptosis; high uric; atherosclerosis; hua ... See more keywords