Conformationally Restricted σ1 Receptor Antagonists from (-)-Isopulegol.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02081
Abstract: Antagonists at σ1 receptors have great potential for the treatment of neuropathic pain. Starting from monoterpene (-)-isopulegol (1), aminodiols 8-11 were obtained and transformed into bicyclic 13-16 and tricyclic ligands 19-22. Aminodiols 8-11 showed higher… read more here.
Keywords: affinity; antagonists isopulegol; conformationally restricted; higher affinity ... See more keywords
Using phage display for rational engineering of a higher-affinity humanized 3’ phosphohistidine-specific antibody
Sign Up to like & getrecommendations! Published in 2025 at "Communications Chemistry"
DOI: 10.1038/s42004-025-01768-9
Abstract: Histidine phosphorylation is a non-canonical post-translational modification (PTM), with 1-phosphohistidine (1-pHis) and 3-phosphohistidine (3-pHis) isoforms, that is understudied due to a lack of robust reagents, including high-affinity pHis-specific antibodies. Engineering pHis antibodies is challenging due… read more here.
Keywords: higher affinity; antibody; engineering; biology ... See more keywords