Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06512-7
Abstract: Selective disruption of synaptic drive to inhibitory neurons could contribute to the pathophysiology of various brain disorders. We have previously identified a GluN2A-selective positive allosteric modulator, GNE-8324, that selectively enhances N-methyl-d-aspartate receptor (NMDAR)-mediated synaptic responses… read more here.
Keywords: excitatory neurons; higher ambient; inhibitory; glutamate inhibitory ... See more keywords
Association between higher ambient temperature and orthopaedic infection rates: a systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2019 at "ANZ Journal of Surgery"
DOI: 10.1111/ans.15089
Abstract: Many infectious diseases display seasonal variation corresponding with particular conditions. In orthopaedics a growing body of evidence has identified surges in post‐operative infection rates during higher temperature periods. The aim of this research was to… read more here.
Keywords: infection rates; association higher; infection; higher ambient ... See more keywords