Scientific rationale for a higher dose of nusinersen
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51562
Abstract: The long‐term favorable safety profile of nusinersen provides an opportunity to consider a higher dose. We report on the relationships between nusinersen cerebrospinal fluid (CSF) exposure, biomarker levels, and clinical efficacy. read more here.
Keywords: neurology; higher dose; dose nusinersen; rationale higher ... See more keywords
Anticoagulant Treatment Regimens in Patients With Covid‐19: A Meta‐Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2504
Abstract: Coronavirus disease 2019 (COVID‐19) is associated with a hypercoagulable state. It has been hypothesized that higher‐dose anticoagulation, including therapeutic‐dose and intermediate‐dose anticoagulation, is superior to prophylactic‐dose anticoagulation in the treatment of COVID‐19. This meta‐analysis evaluated… read more here.
Keywords: patients covid; dose anticoagulation; higher dose; prophylactic dose ... See more keywords
Statistical planning in confirmatory clinical trials with multiple treatment groups, multiple visits, and multiple endpoints
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2017.1378664
Abstract: ABSTRACT Multiplicity issues can be multidimensional: A confirmatory clinical trial may be designed to have efficacy assessed with two or more primary endpoints, for multiple dose groups, and at several post-baseline visits. Controlling for multiplicity… read more here.
Keywords: multiplicity; confirmatory clinical; higher dose; multiple visits ... See more keywords
Is it time to modify the Japanese Uterine Cervical Cancer Guidelines to recommend a higher dose for radio-resistant tumors?
Sign Up to like & getrecommendations! Published in 2022 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyac171
Abstract: Compared with the European or the United States' uterine cervical cancer management guidelines, which aim to deliver >85 Gy EQD2 (the equivalent effective dose in 2 Gy per fraction) to the high-risk clinical target volume (CTVHR) D90… read more here.
Keywords: cervical cancer; higher dose; guidelines recommend; recommend higher ... See more keywords
Differential Effects on Haemostatic Markers by Metformin and the Contraceptive Pill: A Randomized Comparative Trial in PCOS.
Sign Up to like & getrecommendations! Published in 2017 at "Thrombosis and haemostasis"
DOI: 10.1160/th17-04-0248
Abstract: Background Polycystic ovarian syndrome (PCOS) affects up to 18% of reproductive-aged women with increased risks of cardiovascular disease and venous thromboembolic disease, related to metabolic and hormonal features, obesity and an apparent hypofibrinolytic state, possibly exacerbated… read more here.
Keywords: dose ocp; pcos; randomized comparative; higher dose ... See more keywords
Investigating dose–response effects of multimodal exercise programs on health-related quality of life in older adults
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Interventions in Aging"
DOI: 10.2147/cia.s187534
Abstract: Background Older adults are at risk of multiple chronic diseases, most of which could be prevented by engaging in regular physical activity. Frailty is a state of increased vulnerability to diseases. Worsening symptoms of frailty,… read more here.
Keywords: health; older adults; higher dose; frailty ... See more keywords
Treatment Outcomes After Higher-dose Fractionated Stereotactic Radiotherapy (FSRT) Alone for 1-4 Brain Metastases
Sign Up to like & getrecommendations! Published in 2023 at "AntiCancer Research"
DOI: 10.21873/anticanres.16443
Abstract: Background/Aim: Fractionated stereotactic radiotherapy (FSRT) is increasingly used for brain metastases. We investigated higher-dose FSRT with biologically effective doses (BED) of 49.6-66.7 Gy12. Patients and Methods: Eleven characteristics were evaluated for local control (LC), overall… read more here.
Keywords: brain metastases; higher dose; brain; fsrt ... See more keywords
Higher Dose Anticoagulation Cannot Prevent Disease Progression in COVID-19 Patients: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10092194
Abstract: Implementation of higher dose (HD) thromboprophylaxis has been considered in patients infected with coronavirus disease 2019 (COVID-19). Our aim was to compare HD to standard dose (SD) thromboprophylaxis in COVID-19 patients. The protocol is registered… read more here.
Keywords: covid patients; disease; higher dose; covid ... See more keywords