Ribosomal leaky scanning through a translated uORF requires eIF4G2
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1286
Abstract: Abstract eIF4G2 (DAP5 or Nat1) is a homologue of the canonical translation initiation factor eIF4G1 in higher eukaryotes but its function remains poorly understood. Unlike eIF4G1, eIF4G2 does not interact with the cap-binding protein eIF4E… read more here.
Keywords: translated uorf; scanning complexes; scanning translated; leaky scanning ... See more keywords
Specific mechanisms of translation initiation in higher eukaryotes: the eIF4G2 story
Sign Up to like & getrecommendations! Published in 2022 at "RNA"
DOI: 10.1261/rna.079462.122
Abstract: The eukaryotic initiation factor 4G2 (eIF4G2, DAP5, Nat1, p97) was discovered in 1997. Over the past two decades, dozens of papers have presented contradictory data on eIF4G2 function. Since its identification, eIF4G2 has been assumed… read more here.
Keywords: eif4g2; specific mechanisms; translation initiation; higher eukaryotes ... See more keywords
JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.53930
Abstract: More than 30% of genes in higher eukaryotes are regulated by promoter-proximal pausing of RNA polymerase II (Pol II). Phosphorylation of Pol II CTD by positive transcription elongation factor b (P-TEFb) is a necessary precursor… read more here.
Keywords: pol ctd; higher eukaryotes; transcription elongation; pol ... See more keywords