Highly biased agonism for GPCR ligands via nanobody tethering
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DOI: 10.1038/s41467-024-49068-5
Abstract: Ligand-induced activation of G protein-coupled receptors (GPCRs) can initiate signaling through multiple distinct pathways with differing biological and physiological outcomes. There is intense interest in understanding how variation in GPCR ligand structure can be used… read more here.
Keywords: nanobody tethering; highly biased; biased agonism; gpcr ... See more keywords