Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs.
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DOI: 10.1016/j.xphs.2017.09.005
Abstract: Regulatory agencies have recently issued drug-drug interaction guidelines, which require determination of plasma protein binding (PPB). To err on the conservative side, the agencies recommend that a 0.01 lower limit of fraction unbound (fu) be… read more here.
Keywords: highly bound; protein binding; drug interaction; drug ... See more keywords
Improving Confidence in the Determination of Free Fraction for Highly Bound Drugs Using Bidirectional Equilibrium Dialysis.
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DOI: 10.1016/j.xphs.2018.10.011
Abstract: Equilibrium dialysis has been widely used for the measurement of the fraction of unbound drug (fu) in plasma, but it suffers from the accuracy and reliability for low fu values. To address this concern, an… read more here.
Keywords: bound drugs; highly bound; equilibrium dialysis; bidirectional equilibrium ... See more keywords