Highly connected 3D chromatin networks established by an oncogenic fusion protein shape tumor cell identity.
Sign Up to like & getrecommendations! Published in 2023 at "Science advances"
DOI: 10.1126/sciadv.abo3789
Abstract: Cell fate transitions observed in embryonic development involve changes in three-dimensional genomic organization that provide proper lineage specification. Whether similar events occur within tumor cells and contribute to cancer evolution remains largely unexplored. We modeled… read more here.
Keywords: cell; oncogenic fusion; fusion protein; highly connected ... See more keywords
Transcriptome Analysis Revealed a Highly Connected Gene Module Associated With Cirrhosis to Hepatocellular Carcinoma Development
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2019.00305
Abstract: Introduction Cirrhosis is one of the most important risk factors for development of hepatocellular carcinoma (HCC). Recent studies have shown that removal or well control of the underlying cause could reduce but not eliminate the… read more here.
Keywords: hcc; cirrhosis; highly connected; cirrhosis hcc ... See more keywords