Highly conserved epitopes of DENV structural and non-structural proteins: Candidates for universal vaccine targets
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.02.001
Abstract: Abstract Dengue is a severe emerging arthropod borne viral disease occurring globally. Around two fifths of the world's population, or up to 3.9 billion people, are at a risk of dengue infection. Infection induces a… read more here.
Keywords: vaccine targets; conserved epitopes; denv structural; epitopes denv ... See more keywords
Design and testing of a highly conserved human rotavirus VP8* immunogenic peptide with potential for vaccine development.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2018.06.306
Abstract: Rotavirus infection of young children particularly below five years of age resulting in severe diarhoea, is the cause of a large number of infant deaths all over the world, more so in developing countries like… read more here.
Keywords: rotavirus; highly conserved; vaccine; virus ... See more keywords
Reply to: Evaluating two different models of peanut’s origin
Sign Up to like & getrecommendations! Published in 2020 at "Nature Genetics"
DOI: 10.1038/s41588-020-0627-0
Abstract: 1Fujian Provincial Key Laboratory of Plant Molecular and Cell Biology, Oil Crops Research Institute, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, China. 2School of Life Sciences, North China University of Science and… read more here.
Keywords: years ago; divergence; university; peanut ... See more keywords
Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32942-w
Abstract: The Sin3A complex acts as a transcriptional hub, integrating the function of diverse transcription factors with histone modifying enzymes, notably, histone deacetylases (HDAC) 1 and 2. The Sin3A protein sits at the centre of the… read more here.
Keywords: sin3 interaction; interaction domain; interaction; pah1 domain ... See more keywords
Identification of plasticity and interactions of a highly conserved motif within a picornavirus capsid precursor required for virus infectivity
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48170-9
Abstract: The picornavirus family includes poliovirus (PV) (genus: enterovirus), human rhinoviruses (enterovirus) and foot-and-mouth disease virus (FMDV) (aphthovirus). These are responsible for important human and animal health concerns worldwide including poliomyelitis, the common cold and foot-and-mouth… read more here.
Keywords: capsid; virus infectivity; highly conserved; capsid precursor ... See more keywords
A NS1-binding monoclonal antibody interacts with two residues that are highly conserved in seasonal as well as newly emerged influenza A virus
Sign Up to like & getrecommendations! Published in 2019 at "Pathogens and Disease"
DOI: 10.1093/femspd/ftz012
Abstract: &NA; The non‐structural protein 1 (NS1) of influenza A virus (IAV) is a multifunctional protein that antagonizes host antiviral responses, modulating virus pathogenesis. As such, it serves as a good target for research and diagnostic… read more here.
Keywords: two residues; highly conserved; influenza virus; virus ... See more keywords
Highly conserved s2m element of SARS-CoV-2 dimerizes via a kissing complex and interacts with host miRNA-1307-3p
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1226
Abstract: Abstract The ongoing COVID-19 pandemic highlights the necessity for a more fundamental understanding of the coronavirus life cycle. The causative agent of the disease, SARS-CoV-2, is being studied extensively from a structural standpoint in order… read more here.
Keywords: sars cov; highly conserved; kissing complex; s2m element ... See more keywords
Immune responses to highly conserved influenza A virus matrix 1 peptides
Sign Up to like & getrecommendations! Published in 2017 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12485
Abstract: Influenza vaccine development is considered to be complicated and challenging. Constantly evolving influenza viruses require continuous global monitoring and reformulation of the vaccine strains. Peptides that are conserved among different strains and subtypes of influenza… read more here.
Keywords: matrix peptides; pm3; immune responses; influenza virus ... See more keywords
A Highly Conserved Basidiomycete Peptide Synthetase Produces a Trimeric Hydroxamate Siderophore
Sign Up to like & getrecommendations! Published in 2017 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.01478-17
Abstract: ABSTRACT The model white-rot basidiomycete, Ceriporiopsis (Gelatoporia) subvermispora B, encodes putative natural product biosynthesis genes. Among them is the gene for the seven-domain nonribosomal peptide synthetase CsNPS2. It is a member of the as-yet-uncharacterized fungal… read more here.
Keywords: peptide synthetase; csnps2; conserved basidiomycete; siderophore ... See more keywords
A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.01325-19
Abstract: HIV-1 has evolved multiple strategies to avoid humoral responses. One efficient mechanism is to keep its envelope glycoprotein (Env) in its “closed” conformation. Here, we report on a new family of small molecules that are… read more here.
Keywords: highly conserved; hiv; contacts highly; family small ... See more keywords
A Highly Conserved Circular RNA, circRasGEF1B, Enhances Antiviral Immunity by Regulating the miR-21-3p/MITA Pathway in Lower Vertebrates
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.02145-20
Abstract: Siniperca chuatsi rhabdovirus (SCRV) is a typical fish RNA rhabdovirus, which is one of the most significant viral pathogens in teleost fish and can cause severe hemorrhagic septicemia in freshwater and marine fishes. Here, we… read more here.
Keywords: expression; highly conserved; circrasgef1b acts; lower vertebrates ... See more keywords