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Published in 2017 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2017.03.031
Abstract: Abstract A series of bifunctional ruthenium(II) arene compounds modified with bexarotene, a retinoid that selectively activates retinoid X receptors inducing cell differentiation and apoptosis and preventing drug resistance, are described. The bexarotene is tethered to…
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Keywords:
new highly;
cytotoxic organic;
bexarotene;
organic organometallic ... See more keywords
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Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010034
Abstract: Siglec-9 is an MHC-independent inhibitory receptor expressed on a subset of natural killer (NK) cells. Siglec-9 restrains NK cytotoxicity by binding to sialoglycans (sialic acid-containing glycans) on target cells. Despite the importance of Siglec-9 interactions…
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Keywords:
siglec;
hiv infected;
highly cytotoxic;
cytotoxic hiv ... See more keywords
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Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.632540
Abstract: Adoptive natural killer (NK) cell transfer has been demonstrated to be a promising immunotherapy approach against malignancies, but requires the administration of sufficient activated cells for treatment effectiveness. However, the paucity of clinical-grade to support…
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Keywords:
cell expansion;
expansion;
natural killer;
ox40l armed ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084362
Abstract: Due to their manifold biological activities, natural products such as triterpenoids have advanced to represent excellent leading structures for the development of new drugs. For this reason, we focused on the syntheses and cytotoxic evaluation…
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Keywords:
scaffold highly;
cytotoxicity;
madecassic acid;
highly cytotoxic ... See more keywords
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Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14061174
Abstract: This study shows the potential of a thermally induced human serum albumin (HSA) hydrogel to serve as a drug depot for sustained release of a highly cytotoxic modified paullone ligand bearing a TEMPO free radical…
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Keywords:
release highly;
highly cytotoxic;
hydrogel;
hsa ... See more keywords