Highly Functionalized Brønsted Acidic/Lewis Basic Hybrid Ferrocene Ligands: Synthesis and Coordination Chemistry
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Inorganic Chemistry"
DOI: 10.1002/ejic.201801378
Abstract: A general challenging issue in the synthesis of hemilabile ferrocene ligands is the access to highly functionalized ferrocene starting materials. These can bear donor/acceptor atoms, additional functional and structuring spectator substituents, but the preparation of… read more here.
Keywords: hybrid ferrocene; ferrocene; acidic lewis; chemistry ... See more keywords
Multicomponent reaction for the synthesis of highly functionalized piperidine scaffolds catalyzed by TMSI
Sign Up to like & getrecommendations! Published in 2020 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-020-04208-6
Abstract: An efficient method for the synthesis of highly functionalized piperidines via one-pot domino reaction of β-ketoesters, aromatic aldehydes, and aromatic amines was reported. This multicomponent coupling was catalyzed by TMSI in methanol at room temperature,… read more here.
Keywords: synthesis highly; highly functionalized; multicomponent reaction; catalyzed tmsi ... See more keywords
One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine Pancreatic Lipase
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-019-8277-4
Abstract: A series of highly functionalized 1,4-dihydropyridines was synthesized via one-pot multicomponent reactions of aromatic aldehyde, malononitrile and N-methyl-1-(methylthio)-2-nitroethenamine using Porcine pancreatic lipase(PPL) as catalyst in DMSO. This protocol is featured by mild reaction conditions, simple… read more here.
Keywords: porcine pancreatic; highly functionalized; pot multicomponent; using porcine ... See more keywords
A new synthesis of highly functionalized cyclohexenes via a vinylogous Ferrier-Petasis cyclization reaction
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.10.055
Abstract: Abstract Research on the O→C rearrangement reaction shows that alkoxydienes undergo a smooth rearrangement in a vinylogous manner with a catalytic amount of titanium (IV) chloride, which leads to highly substituted cyclohexenes a particularly useful… read more here.
Keywords: new synthesis; functionalized cyclohexenes; reaction; synthesis highly ... See more keywords
Highly functionalized cyclic and bicyclic β−amino acids from sugar β−nitroesters
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DOI: 10.1016/j.tet.2019.130837
Abstract: Abstract The synthesis of highly functionalized bicyclic and cyclic β-amino acids from β-nitrosugars is reported. Specifically, our strategy for the synthesis of polyhydroxylated cyclopentane β-amino acids via the intramolecular C-alkylation of 6-nitro-2-O-triflates of furanosides has… read more here.
Keywords: amino; amino acids; bicyclic amino; highly functionalized ... See more keywords
Lewis acid-catalyzed cyclodimerization of 1-substituted-3-arylvinylindoles leading to highly functionalized fused cyclopenta[b]indoles
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151453
Abstract: Abstract An unexpected Lewis acid-catalyzed [3+2] cycloaddition reaction of 1-substituted-3-arylvinylindoles was revealed when we studied the chemistry of donor-acceptor cyclobutanes and 1-substituted-3-arylvinylindoles. This method provides a simple, efficient route to synthesis of highly functionalized fused… read more here.
Keywords: lewis acid; fused cyclopenta; substituted arylvinylindoles; functionalized fused ... See more keywords
An Access to Highly Functionalized Dihydrobenzofuran Spirooxindole Scaffolds.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03123
Abstract: We have developed an efficient protocol for the construction of polycyclic dihydrobenzofuran spirooxindole scaffolds via base promoted cascade annulation of Morita-Baylis-Hillman (MBH) carbonates of isatins with ortho-hydroxychalcones or ortho-hydroxy-β-nitrostyrenes. The complex polycyclic compounds were conveniently… read more here.
Keywords: highly functionalized; functionalized dihydrobenzofuran; dihydrobenzofuran spirooxindole; dihydrobenzofuran ... See more keywords
Disproportionation-Inspired Construction of Highly Functionalized Bicyclo[3.2.1]octanes.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00397
Abstract: The formation of one unavoidable byproduct in traditional disproportionation reactions limits their applications in synthesis. Inspired by convergent disproportionation, we develop an iodine-induced cyclization and oxidation of allylic alcohols to produce highly functionalized bicyclo[3.2.1]octanes through… read more here.
Keywords: highly functionalized; disproportionation inspired; functionalized bicyclo; bicyclo octanes ... See more keywords
Stereoselective Synthesis of Highly Functionalized Cyclohexenes via Strong-Acid-Mediated Endocyclic C-C Bond Cleavage of Monocyclopropanated Cyclopentadienes.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00935
Abstract: A stereoselective, solvent- and metal-free endocyclic C-C bond cleavage of monocyclopropanated cyclopentadienes mediated by strong acids was developed, leading to highly functionalized six-membered carbocycles with high stereocontrol. The critical step for this ring-expansion is the… read more here.
Keywords: monocyclopropanated cyclopentadienes; highly functionalized; bond cleavage; cleavage monocyclopropanated ... See more keywords
A One-Pot Synthesis of Highly Functionalized Purines.
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DOI: 10.1021/acs.orglett.7b03209
Abstract: Highly substituted purines were synthesized in good to high yields through a one-pot straightforward metal-free scalable method, using the Traube synthesis adapted to Vilsmeier-type reagents. From 5-amino-4-chloropyrimidines, new 9-aryl-substituted chloropurines and intermediates for peptide nucleic… read more here.
Keywords: pot synthesis; one pot; synthesis highly; highly functionalized ... See more keywords
Access to Highly Functionalized Indanes from Arynes and α,γ-Diketo Esters.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03919
Abstract: An unprecedented method for the synthesis of highly functionalized indanes from arynes and α,γ-diketo esters is described. Importantly, mild and nearly pH-neutral conditions ensure excellent functional group tolerance. Theoretical studies indicated that the reaction proceeds… read more here.
Keywords: arynes diketo; indanes arynes; diketo esters; functionalized indanes ... See more keywords