EGFR‐rich extracellular vesicles derived from highly metastatic nasopharyngeal carcinoma cells accelerate tumour metastasis through PI3K/AKT pathway‐suppressed ROS
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12003
Abstract: Abstract Nasopharyngeal carcinoma (NPC) is the most common cancer with high metastatic potential that occurs in the epithelial cells of the nasopharynx. Distant metastases are the primary cause for treatment failure and mortality of NPC… read more here.
Keywords: extracellular vesicles; metastatic npc; npc; npc cells ... See more keywords
Highly‐metastatic colorectal cancer cell released miR‐181a‐5p‐rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12186
Abstract: Abstract Liver metastasis of colorectal cancer (CRLM) is the most common cause of CRC‐related mortality, and is typically caused by interactions between CRC cells and the tumour microenvironment (TME) in the liver. However, the molecular… read more here.
Keywords: mir 181a; crc; colorectal cancer; liver metastasis ... See more keywords
A rare subpopulation of melanoma cells with low expression of metastasis suppressor NME1 is highly metastatic in vivo
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DOI: 10.1038/s41598-020-58996-3
Abstract: Despite recent advances in melanoma treatment, metastasis and resistance to therapy remain serious clinical challenges. NME1 is a metastasis suppressor, a class of proteins which inhibits metastatic spread of cancer cells without impact on growth… read more here.
Keywords: melanoma; rare subpopulation; metastasis; highly metastatic ... See more keywords
miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells
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DOI: 10.1038/s41598-021-92879-5
Abstract: Tumor endothelial cells (TECs) reportedly exhibit altered phenotypes. We have demonstrated that TECs acquire drug resistance with the upregulation of P-glycoprotein (P-gp, ABCB1), contrary to traditional assumptions. Furthermore, P-gp expression was higher in TECs of… read more here.
Keywords: drug resistance; metastatic tumor; highly metastatic; resistance ... See more keywords
SREKA-targeted liposomes for highly metastatic breast cancer therapy
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DOI: 10.1080/10717544.2023.2174210
Abstract: Abstract Chemotherapy is still a leading therapeutic approach in various tumor types that is often accompanied by a poor prognosis because of metastases. PEGylated liposomes with CREKA targeting moiety are well-known therapeutic agents, especially in… read more here.
Keywords: dspe pegs; sreka; targeting moiety; tumor ... See more keywords
Comparison of Tumor Recurrence After Resection of Highly- and Poorly-Metastatic Triple-negative Breast Cancer in Orthotopic Nude-Mouse Models.
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DOI: 10.21873/anticanres.11288
Abstract: BACKGROUND Triple-negative breast cancer (TNBC), defined by the absence of receptors for estrogen, progesterone and human epithelial receptor 2, is a recalcitrant disease in need of effective therapy. We previously isolated highly-metastatic variants of the… read more here.
Keywords: mda; recurrence; mda 231; highly metastatic ... See more keywords
Highly Metastatic Subpopulation of TNBC Cells Has Limited Iron Metabolism and Is a Target of Iron Chelators
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DOI: 10.3390/cancers15020468
Abstract: Simple Summary Excess iron is known to be a risk factor of carcinogenesis. Although iron chelators show anti-cancer effects, they have not been used successfully to treat cancer patients. Triple-negative breast cancer (TNBC) is a… read more here.
Keywords: iron chelators; iron; tnbc; tnbc cells ... See more keywords
Sulforaphane has an additive anticancer effect to FOLFOX in highly metastatic human colon carcinoma cells.
Sign Up to like & getrecommendations! Published in 2022 at "Oncology reports"
DOI: 10.3892/or.2022.8420
Abstract: Colorectal cancer (CRC) is one of the most common malignancies worldwide. Patients with CRC may need chemotherapy (CTx) in a neoadjuvant, adjuvant or palliative setting through the course of the disease. Unfortunately, its effect is… read more here.
Keywords: metastatic human; effect; human colon; crc ... See more keywords