The spike glycoprotein of highly pathogenic human coronaviruses: structural insights for understanding infection, evolution and inhibition
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13454
Abstract: Highly pathogenic human coronaviruses (CoV) including SARS‐CoV, MERS‐CoV and SARS‐CoV‐2 have emerged over the past two decades, resulting in infectious disease outbreaks that have greatly affected public health. The CoV surface spike (S) glycoprotein mediates… read more here.
Keywords: pathogenic human; glycoprotein; human coronaviruses; highly pathogenic ... See more keywords
Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202207249
Abstract: Highly pathogenic coronavirus (CoV) infection induces a defective innate antiviral immune response coupled with the dysregulated release of proinflammatory cytokines and finally results in acute respiratory distress syndrome (ARDS). A timely and appropriate triggering of… read more here.
Keywords: immune responses; pathogenic coronavirus; antiviral nanobiologic; innate immune ... See more keywords
The virulence factor PA protein of highly pathogenic H5N1 avian influenza virus inhibits NF-κB transcription in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Virology"
DOI: 10.1007/s00705-017-3496-9
Abstract: Nuclear factor kappa B (NF-κB) plays a crucial role in inflammation and immune responses. Our previous studies have demonstrated that the innate immune response affect H5N1 virus virulence in mice. In this study, we first… read more here.
Keywords: avian influenza; highly pathogenic; influenza virus; factor ... See more keywords
Cottontail rabbits shed clade 2.3.4.4 H5 highly pathogenic avian influenza A viruses
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Virology"
DOI: 10.1007/s00705-018-3907-6
Abstract: During 2014-2015, clade 2.3.4.4 H5Nx highly pathogenic (HP) avian influenza A viruses (IAV) were first detected in North America and subsequently caused one of the largest agricultural emergencies in U.S. history. Recent evidence has suggested… read more here.
Keywords: avian influenza; influenza viruses; highly pathogenic; cottontail rabbits ... See more keywords
Downregulation of miR-296-3p by highly pathogenic porcine reproductive and respiratory syndrome virus activates the IRF1/TNF-α signaling axis in porcine alveolar macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Virology"
DOI: 10.1007/s00705-020-04921-y
Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV, species Betaarterivirus suid 1 or 2 ) is a major pathogen affecting pigs on farms throughout the world. miR-296-3p is a multifunctional microRNA involved in the regulation of… read more here.
Keywords: tnf; highly pathogenic; infection; porcine ... See more keywords
A conserved multi-epitope-based vaccine designed by targeting hemagglutinin protein of highly pathogenic avian H5 influenza viruses
Sign Up to like & getrecommendations! Published in 2020 at "3 Biotech"
DOI: 10.1007/s13205-020-02544-3
Abstract: The highly pathogenic avian H5N1 influenza viruses have been recognized as a potential pandemic threat to humans, and to the poultry industry since 1997. H5 viruses consist of a high mutation rate, so universal vaccine… read more here.
Keywords: influenza viruses; highly pathogenic; vaccine; pathogenic avian ... See more keywords
CD163 knockout pigs are fully resistant to highly pathogenic porcine reproductive and respiratory syndrome virus
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.01.004
Abstract: ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) causes severe economic losses to current swine production worldwide. Highly pathogenic PRRSV (HP‐PRRSV), originated from a genotype 2 PRRSV, is more virulent than classical PRRSV and further… read more here.
Keywords: cd163 knockout; highly pathogenic; cd163; virus ... See more keywords
Neuraminidase inhibitors susceptibility profiles of highly pathogenic influenza A (H5N1) viruses isolated from avian species in India (2006-2015).
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral research"
DOI: 10.1016/j.antiviral.2018.08.007
Abstract: We tested 65 highly pathogenic avian influenza (HPAI) A(H5N1) viruses, isolated from avian species in India between 2006 and 2015, for susceptibility to the FDA approved neuraminidase (NA) inhibitors (NAIs), oseltamivir and zanamivir using a… read more here.
Keywords: viruses isolated; highly pathogenic; isolated avian; h5n1 ... See more keywords
Neutralizing monoclonal antibodies against highly pathogenic coronaviruses
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Virology"
DOI: 10.1016/j.coviro.2021.12.015
Abstract: The pandemic of Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 coronavirus (SARS-CoV-2) is a continuing worldwide threat to human health and social economy. Historically, SARS-CoV-2 follows SARS and MERS as the… read more here.
Keywords: sars cov; neutralizing monoclonal; antibodies highly; monoclonal antibodies ... See more keywords
International chicken trade and increased risk for introducing or reintroducing highly pathogenic avian influenza A (H5N1) to uninfected countries
Sign Up to like & getrecommendations! Published in 2017 at "Infectious Disease Modelling"
DOI: 10.1016/j.idm.2017.09.001
Abstract: Every year billions of chickens are shipped thousands of miles around the globe in order to meet the ever increasing demands for this cheap and nutritious protein source. Unfortunately, transporting chickens internationally can also increase… read more here.
Keywords: avian influenza; risk; highly pathogenic; infection ... See more keywords
Use of M2e ELISAs for longitudinal surveillance of commercial poultry in Indonesia vaccinated against highly pathogenic avian influenza.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of virological methods"
DOI: 10.1016/j.jviromet.2017.08.014
Abstract: In countries where highly pathogenic avian influenza virus (HPAIV) H5N1 is endemic and controlled by vaccination, post-vaccination serological monitoring is essential to differentiate vaccinated poultry from those that are infected. The objectives of this study… read more here.
Keywords: avian influenza; highly pathogenic; influenza; h5n1 ... See more keywords