Highly Preorganized Calixarene Tweezers for Protein Recognition.
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DOI: 10.1021/acs.biomac.5c00803
Abstract: Calixarene scaffolds offer structural robustness and tunable geometry for designing selective supramolecular inhibitors. Here, we developed a focused library of preorganized multivalent calix[4]arene tweezers targeting the cancer-related protease Taspase 1. Seven cone-conformation derivatives were synthesized,… read more here.
Keywords: tweezers protein; calixarene; preorganized calixarene; highly preorganized ... See more keywords