Kidney transplantation of highly sensitized recipients under the new kidney allocation system: A reflection from five different transplant centers across the United States.
Sign Up to like & getrecommendations! Published in 2017 at "Human immunology"
DOI: 10.1016/j.humimm.2016.10.009
Abstract: Deceased donor kidney allocation was reorganized in the United States to address several problems, including the highly sensitized patients disadvantaged with large, diverse repertoires of antibodies. Here, five transplant surgeons review their center's experience with… read more here.
Keywords: highly sensitized; transplantation; united states; kidney allocation ... See more keywords
P064 Kidney allocation strategy for highly sensitized patients based on epitope virtual crossmatch: Pernambuco experience
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.124
Abstract: Aim Brazil has a public transplant program. Potential recipients are ranking by HLA match, age, time in waiting list and PRA > 50%. However, transplantability among highly sensitized patients is 10 times lower than among non-highly sensitized.… read more here.
Keywords: sensitized patients; allocation strategy; kidney allocation; highly sensitized ... See more keywords
OR6 Successful deceased donor kidney transplantation of highly sensitized candidates across positive cross match and strong donor-specific HLA-DP antibodies without desensitization
Sign Up to like & getrecommendations! Published in 2018 at "Human Immunology"
DOI: 10.1016/j.humimm.2018.07.011
Abstract: Aim Over 50% of kidney transplant (Ktx) candidates with 100% CPRA display HLA-DP antibodies, which impair the chances of finding a compatible deceased donor (DD) despite national sharing. Herein, we assessed the impact of donor-specific… read more here.
Keywords: dsa; hla antibodies; highly sensitized; donor ... See more keywords
#1016 Kidney transplantation in highly sensitized patients with preformed donor-specific antibodies through personalized delisting strategies
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DOI: 10.1093/ndt/gfae069.975
Abstract: This study explores a personalized delisting strategy enabling kidney transplantation in highly sensitized patients with preformed donor-specific anti-HLA antibodies (DSA) trying to minimize the risk of antibody-mediated rejection (ABMR). Retrospective single-centre analysis of 50 kidney… read more here.
Keywords: kidney transplantation; highly sensitized; transplantation highly; sensitized patients ... See more keywords
#724 Kidney transplant outcomes in highly sensitized patients with preformed donor-specific antibodies using a DELISTING strategy
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DOI: 10.1093/ndt/gfaf116.0824
Abstract: Highly sensitized patients represent a significant challenge in kidney transplantation (KT) due to the limited availability of compatible donors and the high risk of antibody-mediated rejection. In this context, the delisting of forbidden HLA antigens… read more here.
Keywords: specific antibodies; preformed donor; transplant; donor specific ... See more keywords
Analysis of Kidney Transplantation Results of Very Highly Sensitized Patients Included in a Virtual Crossmatch Programme and their Kidney Pairs. Results of 5 Years Since the Beginning of the Protocol. Andalusian Group for Highly Sensitized Patients
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/01.tp.0000543445.27772.2c
Abstract: Andalusian Group for Highly Sensitized Patients. Background Organ-exchange strategies based on virtual crossmatch (V-XM) can improve kidney transplantation in very highly-sensitized (HS) patients. Methods Andalusia started a V-XM protocol for very-HS patients in june, 2012… read more here.
Keywords: group; kidney transplantation; highly sensitized; sensitized patients ... See more keywords
Does the Canadian allocation system for highly sensitized patients work?
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DOI: 10.1097/mot.0000000000000635
Abstract: PURPOSE OF REVIEW The number of sensitized heart transplant candidates is rising. Highly sensitized patients are disadvantaged because they encounter longer waiting times to heart transplant. Strategies to reduce their waiting times include waitlist prioritization… read more here.
Keywords: transplant; highly sensitized; sensitized patients; allocation system ... See more keywords
The Introduction of cPRA and Its Impact on Access to Deceased Donor Kidney Transplantation for Highly Sensitized Patients in Australia.
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DOI: 10.1097/tp.0000000000003410
Abstract: BACKGROUND In March 2016, Australia's deceased donor kidney allocation program introduced calculated panel reactive antibody (cPRA) based on antibody exclusions using multiplex assays to define sensitization for waitlisted candidates. We aimed to assess the impact… read more here.
Keywords: introduction cpra; highly sensitized; sensitized patients; deceased donor ... See more keywords
Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients
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DOI: 10.1111/ajt.15486
Abstract: Whereas regular allocation avoids unacceptable mismatches on the donor organ, allocation to highly sensitized patients within the Eurotransplant Acceptable Mismatch (AM) program is based on the patient's HLA phenotype plus acceptable antigens. These are HLA… read more here.
Keywords: rejection; highly sensitized; regular allocation; sensitized patients ... See more keywords
Addition of interleukin‐6 receptor blockade to carfilzomib‐based desensitization in a highly sensitized nonhuman primate model
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DOI: 10.1111/ajt.17208
Abstract: Sensitized patients, those who had prior exposure to foreign human leukocyte antigens, are transplanted at lower rates due to challenges in finding suitable organs. Desensitization strategies have permitted highly sensitized patients to undergo kidney transplantation,… read more here.
Keywords: desensitization; nonhuman primate; interleukin receptor; receptor ... See more keywords