Targeting Unique Epitopes on Highly Similar Proteins GDF-11 and GDF-8 with Modified DNA Aptamers.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00760
Abstract: The mature forms of the TGF-β family members GDF-11 and GDF-8 are highly similar 25 kDa homodimers with 90% amino acid sequence identity and 99% similarity. Cross-reactivity of GDF-11 and GDF-8 binding reagents is common… read more here.
Keywords: affinity; selection; gdf; gdf gdf ... See more keywords
Highly Similar Sequence and Structure Yet Different Biophysical Behavior: A Computational Study of Two Triosephosphate Isomerases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c01501
Abstract: Homodimeric triosephosphate isomerases (TIMs) from Trypanosoma cruzi (TcTIM) and Trypanosoma brucei (TbTIM) have markedly similar amino-acid sequences and three-dimensional structures. However, several of their biophysical parameters, such as their susceptibility to sulfhydryl agents and their… read more here.
Keywords: highly similar; sequence structure; triosephosphate isomerases; triosephosphate ... See more keywords
Preprint Highlight: Transcriptomic changes highly similar to Alzheimer's disease are observed in a subpopulation of individuals during normal brain aging.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.p22-03-1007
Abstract: Relatively few studies have addressed how aging contributes to late-onset Alzheimer's disease (LOAD) development and the mechanisms remain largely unknown. Here the authors integrate gene expression data from ∼1000 brains, comparing normal aging with LOAD… read more here.
Keywords: alzheimer disease; brain; highly similar; load ... See more keywords
To Identify Tree Species With Highly Similar Leaves Based on a Novel Attention Mechanism for CNN
Sign Up to like & getrecommendations! Published in 2019 at "IEEE Access"
DOI: 10.1109/access.2019.2951607
Abstract: Image identification technology has great significance for forestry production and forestry management. Highly similar object identification tasks, such as tree species with similar leaves, are extremely challenging. Simply using typical Convolutional Neural Networks (CNNs) or… read more here.
Keywords: branch; similar leaves; highly similar; attention ... See more keywords
Large EEG amplitude effects are highly similar across Necker cube, smiley, and abstract stimuli
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0232928
Abstract: The information available through our senses is noisy, incomplete, and ambiguous. Our perceptual systems have to resolve this ambiguity to construct stable and reliable percepts. Previous EEG studies found large amplitude differences in two event-related… read more here.
Keywords: visibility; erp effects; cube; amplitude effects ... See more keywords
Engineering protein glycosylation in CHO cells to be highly similar to murine host cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1113994
Abstract: Since 2015 more than 34 biosimilars have been approved by the FDA. This new era of biosimilar competition has stimulated renewed technology development focused on therapeutic protein or biologic manufacturing. One challenge in biosimilar development… read more here.
Keywords: cell; murine; highly similar; glycosylation ... See more keywords