Rational Design of a Highly Specific Prolyl Endopeptidase To Activate the Antihypertensive Effect of Peptides
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200691
Abstract: Enzymatic hydrolysis of food‐derived proteins to produce bioactive peptides could activate food functions such as antihypertension. However, the diversity of enzymatic hydrolysis products can reduce bioactive peptides’ efficacy. Highly specific proteases can homogenize the hydrolysis… read more here.
Keywords: prolyl endopeptidase; bioactive peptides; highly specific; antihypertensive effect ... See more keywords
Clinical implications for biochemical diagnostic thresholds of adrenal sufficiency using a highly specific cortisol immunoassay.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2017.02.008
Abstract: OBJECTIVES Recent guidelines recommend a diagnosis of adrenal insufficiency when a stimulated peak cortisol level falls below 500nmol/L. This may not be valid using a highly specific cortisol immunoassay or liquid chromatography-mass spectroscopy (LCMS/MS). We… read more here.
Keywords: cortisol; highly specific; cortisol immunoassay; diagnostic thresholds ... See more keywords
PEP-PREDNa+: A web server for prediction of highly specific peptides targeting voltage-gated Na+ channels using machine learning techniques.
Sign Up to like & getrecommendations! Published in 2022 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2022.105414
Abstract: Voltage-gated sodium channel activity has long been associated with several diseases including epilepsy, chronic pain, cardiovascular diseases, cancers, immune system, neuromuscular and respiratory disorders. The strong participation of these channels in the development of diseases… read more here.
Keywords: pep predna; prediction; highly specific; voltage gated ... See more keywords
A highly specific Serratia-infecting T7-like phage inhibits biofilm formation in two different genera of the Enterobacteriaceae family.
Sign Up to like & getrecommendations! Published in 2021 at "Research in microbiology"
DOI: 10.1016/j.resmic.2021.103869
Abstract: Due to the emergence of multidrug-resistant bacteria, bacteriophages have become a viable alternative in controlling bacterial growth or biofilm formation. Biofilm is formed by extracellular polymeric substances (EPS) and is one of the factors responsible… read more here.
Keywords: highly specific; serratia; phage; biofilm formation ... See more keywords
Design Principles, Sensing Mechanisms, and Applications of Highly Specific Fluorescent Probes for HOCl/OCl.
Sign Up to like & getrecommendations! Published in 2019 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.9b00307
Abstract: Hypochlorous acid/hypochlorite (HOCl/OCl-), one of the most important reactive oxygen species (ROS), plays vital roles in various physiological and pathological processes. At normal concentrations, OCl- acts as part of an immune defense system by destroying… read more here.
Keywords: hocl ocl; highly specific; fluorescent; detection ocl ... See more keywords
Anaerobic Benzene Biodegradation Linked to the Growth of Highly Specific Bacterial Clades.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental science & technology"
DOI: 10.1021/acs.est.1c00508
Abstract: Reliance on bioremediation to remove benzene from anoxic environments has proven risky for decades but for unknown reasons. Research has revealed a strong link between anaerobic benzene biodegradation and the enrichment of highly specific microbes,… read more here.
Keywords: highly specific; benzene biodegradation; benzene; growth ... See more keywords
A Multifunctional Lipid-based Nanodevice for the Highly-specific Co-delivery of Sorafenib and Midkine siRNA to Hepatic Cancer Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00738
Abstract: Hepatocellular carcinoma (HCC), a common deadly malignancy, requires novel therapeutic strategies to improve the survival rate. Combining chemotherapy and gene therapy is a promising approach for increasing efficiency and reducing side effects. We report on… read more here.
Keywords: specific delivery; highly specific; delivery; hepatic cancer ... See more keywords
Highly Specific Protein Identification by Immunoprecipitation–Mass Spectrometry Using Antifouling Microbeads
Sign Up to like & getrecommendations! Published in 2022 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.1c22734
Abstract: A common method to study protein complexes is immunoprecipitation (IP), followed by mass spectrometry (thus labeled: IP-MS). IP-MS has been shown to be a powerful tool to identify protein–protein interactions. It is, however, often challenging… read more here.
Keywords: specific protein; highly specific; mass spectrometry; protein ... See more keywords
Rational-Differential Design of Highly Specific Glycomimetic Ligands: Targeting DC-SIGN and Excluding Langerin Recognition.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00958
Abstract: At the surface of dendritic cells, C-type lectin receptors (CLRs) allow the recognition of carbohydrate-based PAMPS or DAMPS (pathogen- or danger-associated molecular patterns, respectively) and promote immune response regulation. However, some CLRs are hijacked by… read more here.
Keywords: highly specific; differential design; sign; recognition ... See more keywords
Highly specific multiplexed RNA imaging in tissues with split-FISH
Sign Up to like & getrecommendations! Published in 2020 at "Nature Methods"
DOI: 10.1038/s41592-020-0858-0
Abstract: We present split-FISH, a multiplexed fluorescence in situ hybridization method that leverages a split-probe design to achieve enhanced specificity. Split-FISH reduces off-target background fluorescence, decreases false positives and enables accurate RNA profiling in uncleared tissues.… read more here.
Keywords: multiplexed rna; highly specific; tissues split; specific multiplexed ... See more keywords
A highly specific and sensitive nanoimmunosensor for the diagnosis of neuromyelitis optica spectrum disorders
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52506-w
Abstract: A precise diagnosis for neuromyelitis optica spectrum disorders (NMOSD) is crucial to improve patients’ prognostic, which requires highly specific and sensitive tests. The cell-based assay with a sensitivity of 76% and specificity of 100% is… read more here.
Keywords: diagnosis neuromyelitis; spectrum disorders; highly specific; aqp4 ... See more keywords