Highly Stereoselective Synthesis of Imidazolidines through the Palladium(0)‐Catalyzed Three‐Component Reaction of 2,3‐Allenylamines, Organic Halides, and Imines
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DOI: 10.1002/cctc.201601345
Abstract: A new and efficient method for the synthesis of polysubstituted imidazolidines through the Pd0‐catalyzed double addition/cyclization of 2,3‐allenylamines with aryl iodides and imines was explored. This catalytic reaction afforded the desired products in good yields… read more here.
Keywords: highly stereoselective; imidazolidines palladium; stereoselective synthesis; synthesis imidazolidines ... See more keywords
Highly Stereoselective Synthesis of New Aziridines via Baldwin Rearrangement and Their Potential Biological Activities
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2548
Abstract: An atom-economical conversion of N-substituted isoxazoline derivatives to new N-substituted aziridines has been described using microwave irradiation through Baldwin rearrangement. N-substituted isoxazoline derivatives have been synthesized using a variety of nitrones and alkynes via 1,3-dipolar… read more here.
Keywords: highly stereoselective; synthesis new; stereoselective synthesis; baldwin rearrangement ... See more keywords
Highly stereoselective trifluoropyruvate-ene reaction with Δ20(22)-steroidal olefin by chiral Pd2+-catalyst: New type of VDR antagonist for osteocalcin, Δ20(21)-ene product without (dehydro)lactone and lactam motifs
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2018.05.010
Abstract: Abstract The highly stereoselective trifluoropyruvate-ene reaction with steroidal 1,1-disubstituted Δ20(22)-side chain olefin was achieved by the dicationic BINAP-Pd complex as an effective chiral Lewis acid catalyst to give the Δ20(21)-steroidal ene-product in high yield and… read more here.
Keywords: stereoselective trifluoropyruvate; ene; highly stereoselective; trifluoropyruvate ene ... See more keywords
Highly Stereoselective Asymmetric Total Synthesis of (-)-Jimenezin via Sequential Intramolecular Amide Enolate Alkylation.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00196
Abstract: A highly stereoselective asymmetric total synthesis of (-)-jimenezin (1), a potent anticancer acetogenin, was efficiently completed with the key feature being a sequential intramolecular amide enolate alkylation (IAEA). Our investigation to probe the origin of… read more here.
Keywords: highly stereoselective; sequential intramolecular; stereoselective asymmetric; total synthesis ... See more keywords
Dynamic Kinetic Resolution-Enabled Highly Stereoselective Nucleophilic Fluoroalkylation to Access Chiral β-Fluoro Amines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02250
Abstract: β-Fluorinated amine is highly desirable for biological and pharmaceutical science, because replacing a C-H bond with a C-F bond can change the physical and chemical properties of the parent molecule to a large extent but… read more here.
Keywords: highly stereoselective; stereoselective nucleophilic; chiral fluoro; dynamic kinetic ... See more keywords
Highly Stereoselective Assembly of 1,2-cis-Arap Linkages.
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DOI: 10.1021/acs.orglett.3c00670
Abstract: Highly stereoselective construction of 1,2-cis-Arap linkages has been achieved, which featured a broad range of alcoholic acceptors, including strong nucleophiles and complex bioactive molecules. This method was applied to a regioselective and orthogonal one-pot synthesis… read more here.
Keywords: cis arap; arap linkages; stereoselective assembly; highly stereoselective ... See more keywords
Total Synthesis of Immunosuppressive Mycestericin E and G Enabled by a Highly Stereoselective Nitroso-Ene Cyclization.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01082
Abstract: This report describes a streamlined synthesis of immunosuppressive mycestericin E and G through a highly stereoselective nitroso-ene cyclization in 11-12 steps using readily available materials. The stereochemical outcome in the formation of a Nα-quaternary stereogenic… read more here.
Keywords: synthesis immunosuppressive; stereoselective nitroso; nitroso ene; highly stereoselective ... See more keywords
Highly stereoselective and enantiodivergent synthesis of cyclopropylphosphonates with engineered carbene transferases
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc01965e
Abstract: Organophosphonate compounds have represented a rich source of biologically active compounds, including enzyme inhibitors, antibiotics, and antimalarial agents. Here, we report the development of a highly stereoselective strategy for olefin cyclopropanation in the presence of… read more here.
Keywords: enantiodivergent synthesis; stereoselective enantiodivergent; carbene; highly stereoselective ... See more keywords