The simple and “green” synthesis of highly substituted furan derivatives containing rare 5-amino-3-aroylfuran moiety
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152798
Abstract: Abstract The reaction of potassium 2-aroyl-1,3-dicyano-1,3-bis-methoxycarbonylpropenides with hydrogen peroxide is unusual for compounds of this type and results in formation of highly substituted 5-amino-3-aroylfuran derivatives. In contrast to few related literature methods leading to formation… read more here.
Keywords: synthesis; moiety; highly substituted; amino aroylfuran ... See more keywords
Diastereoselective synthesis of highly substituted tetrahydroquinolines using benzoylacetonitrile via aza Diels–Alder reaction
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2021.153063
Abstract: Abstract Diastereoselective aza-Diels–Alder reaction between in situ generated 2-aminophenyl-substituted enones and α-cyano-α,β-unsaturated aromatic ketone has been developed. In the presence of TEA as a catalyst prepared highly substituted tetrahydroquinolines with an all-carbon quaternary center in… read more here.
Keywords: aza diels; alder reaction; highly substituted; diels alder ... See more keywords
Kinetics and Mass Yields of Aqueous Secondary Organic Aerosol from Highly Substituted Phenols Reacting with a Triplet Excited State.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental science & technology"
DOI: 10.1021/acs.est.1c00575
Abstract: Biomass burning emits large amounts of phenols, which can partition into cloud/fog drops and aerosol liquid water (ALW) and react to form aqueous secondary organic aerosol (aqSOA). Triplet excited states of organic compounds (3C*) are… read more here.
Keywords: substituted phenols; triplet; highly substituted; rate ... See more keywords
Cascade 8π Electrocyclization/Benzannulation to Access Highly Substituted Phenylpyridines.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02968
Abstract: A cascade 8π electrocyclization/benzannulation reaction was developed to obtain the synthetically important highly substituted phenyl-pyridines. This method shows great potential in the rapid and inexpensive application of the scalable and operationally simple production of accessible… read more here.
Keywords: electrocyclization benzannulation; highly substituted; cascade electrocyclization; benzannulation access ... See more keywords
Highly Substituted Acephenanthrylenes and Their π-Extended Derivatives: Syntheses, Structural Analyses, and Properties.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01778
Abstract: This investigation demonstrates that a series of (highly) substituted acephenanthrylenes (APs) 2, benzo[l]acephenanthrylene 3, and dicyclopenta[cd,mn]pyrene 4 are easily prepared by palladium-catalyzed cycloaromatization of 2,3-diethynylbiphenyls 1. The first nonpyrolysis synthesis of 4 by two-fold cycloaromatization… read more here.
Keywords: derivatives syntheses; extended derivatives; substituted acephenanthrylenes; syntheses structural ... See more keywords
Synthesis of Highly Substituted Azepanones from 2 H-Azirines by a Stepwise Annulation/Ring-Opening Sequence.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00999
Abstract: Bicyclic aziridines possessing a 1-azabicyclo[4.1.0]heptan-2-one core were prepared from 2 H-azirines by a stepwise annulation sequence involving a diastereoselective allylindanation, an N-acylation, and a ring-closing metathesis to construct the six-membered ring. After hydrogenation or functionalization… read more here.
Keywords: ring opening; azirines stepwise; substituted azepanones; highly substituted ... See more keywords
Aza-Quasi-Favorskii Reaction: Construction of Highly Substituted Aziridines through a Concerted Multibond Rearrangement Process.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c03805
Abstract: A new molecular rearrangement, the aza-Quasi-Favorskii rearrangement, has been developed for the construction of highly substituted aziridines. Electron-deficient O-sulfonyl oximes react readily with α,α-disubstituted acetophenone-derived enolates to furnish highly substituted aziridines via this unprecedented domino… read more here.
Keywords: substituted aziridines; aza quasi; construction highly; quasi favorskii ... See more keywords
Lithium Hexamethyldisilazide-Mediated Enolization of Highly Substituted Aryl Ketones: Structural and Mechanistic Basis of the E/Z Selectivities.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b05057
Abstract: Enolizations of highly substituted acyclic ketones used in the syntheses of tetrasubstituted olefin-based anticancer agents are described. Lithium hexamethyldisilazide (LiHMDS)-mediated enolizations are moderately Z-selective in neat tetrahydrofuran (THF) and E-selective in 2.0 M THF/hexane. The… read more here.
Keywords: mediated enolization; lithium hexamethyldisilazide; highly substituted; enolization highly ... See more keywords
Novel highly substituted thiophene-based n-type organic semiconductor: structural study, optical anisotropy and molecular control
Sign Up to like & getrecommendations! Published in 2020 at "CrystEngComm"
DOI: 10.1039/d0ce01171a
Abstract: Oligothiophenes and their functionalized derivatives have been shown to be a viable option for high-performance organic electronic devices. The functionalization of oligothiophene-based materials allows further tailoring of their properties for specific applications. We have synthesized… read more here.
Keywords: optical anisotropy; thiophene based; highly substituted; semiconductor ... See more keywords
Exploring F/CF3 substituted oxocarbenium ions for the diastereoselective assembly of highly substituted tetrahydrofurans.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc06521e
Abstract: Understanding the influence of emerging fluorinated motifs is of a crucial importance in the context of the exponentially growing exploitation of fluorine in many fields. Herein, we report on the dramatic effect of a local… read more here.
Keywords: substituted tetrahydrofurans; cf3 substituted; oxocarbenium ions; highly substituted ... See more keywords
Novel Set of Highly Substituted Bis-pyridines: Synthesis, Molecular Docking and Drug-Resistant Antibacterial Profile.
Sign Up to like & getrecommendations! Published in 2022 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2022-0196
Abstract: Aims: Development of antimicrobial agents having the ability to prevent bacterial biofilm formation which causes serious health problems, especially with antibiotic-resistant bacterial strains. Materials and methods: The use of 1,3-diaryl enones as structural motifs to… read more here.
Keywords: bis; bis pyridines; substituted bis; drug resistant ... See more keywords