Two-stage designs versus European scaled average designs in bioequivalence studies for highly variable drugs: Which to choose?
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.7452
Abstract: The usual approach to determine bioequivalence for highly variable drugs is scaled average bioequivalence, which is based on expanding the limits as a function of the within-subject variability in the reference formulation. This requires separately… read more here.
Keywords: bioequivalence; highly variable; two stage; variable drugs ... See more keywords
Discovery of a highly variable bug killing fly species, Clytiomya continua (Diptera: Tachinidae: Phasiinae), in Korea with discussion on its systematic status
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Asia-pacific Entomology"
DOI: 10.1016/j.aspen.2021.02.008
Abstract: Abstract At present, the genus Clytiomya of the tribe Gymnosomatini includes four Palaearctic species, which exhibit high intraspecific variability. While studying Korean members of the bug-killing fly subfamily Phasiinae, we discovered C. continua for the… read more here.
Keywords: status; killing fly; highly variable; variable bug ... See more keywords
Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.039
Abstract: Background: Identifying genes that are essential for mouse embryonic development and survival through term is a powerful and unbiased way to discover possible genetic determinants of human developmental disorders. Characterising the changes in mouse embryos… read more here.
Keywords: highly variable; penetrance abnormal; abnormal phenotypes; variable penetrance ... See more keywords
In Vitro Predictive Dissolution Test Should Be Developed and Recommended as a Bioequivalence Standard for the Immediate-Release Solid Oral Dosage Forms of the Highly Variable Mycophenolate Mofetil.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00792
Abstract: The prodrug mycophenolate mofetil (MMF), which is presystemically hydrolyzed into the pharmacologically active compound mycophenolic acid (MPA), has been widely used for the prophylaxis of acute allograft rejection in solid organ transplantation. However, the huge… read more here.
Keywords: dissolution test; dissolution; variability; highly variable ... See more keywords
Results from a UK-wide survey: the nutritional assessment and management of pancreatic resection patients is highly variable
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Clinical Nutrition"
DOI: 10.1038/s41430-021-01063-5
Abstract: Most patients who undergo curative-intent resection for pancreatic cancer are malnourished. This correlates with poor outcomes. There are no guidelines for the nutritional management of these patients. We aimed to establish current UK practice by… read more here.
Keywords: resection; highly variable; wide survey; results wide ... See more keywords
A Deep Learning-Based Wind Field Nowcasting Method With Extra Attention on Highly Variable Events
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Geoscience and Remote Sensing Letters"
DOI: 10.1109/lgrs.2022.3212904
Abstract: Highly variable wind fields (HWFs), which usually have drastically changing velocities over time, can seriously impact aviation safety, wind energy assessment, and so on. A recently proposed deep learning method can well predict the wind… read more here.
Keywords: loss function; variable events; nowcasting method; deep learning ... See more keywords
Highly variable upper and abyssal overturning cells in the South Atlantic
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba7573
Abstract: We present the first-ever daily time series of the full-depth volume transports by the overturning circulation cells at 34.5°S. The Meridional Overturning Circulation (MOC) is a primary mechanism driving oceanic heat redistribution on Earth, thereby… read more here.
Keywords: highly variable; upper abyssal; overturning cells; south atlantic ... See more keywords
GPRED-GC: a Gene PREDiction model accounting for 5 ′- 3′ GC gradient
Sign Up to like & getrecommendations! Published in 2019 at "BMC Bioinformatics"
DOI: 10.1186/s12859-019-3047-3
Abstract: Gene is a key step in genome annotation. Ab initio gene prediction enables gene annotation of new genomes regardless of availability of homologous sequences. There exist a number of ab initio gene prediction tools and… read more here.
Keywords: highly variable; gene prediction; model; gradient ... See more keywords
The bacterial density of clinical rectal swabs is highly variable, correlates with sequencing contamination, and predicts patient risk of extraintestinal infection
Sign Up to like & getrecommendations! Published in 2022 at "Microbiome"
DOI: 10.1186/s40168-021-01190-y
Abstract: Background In ecology, population density is a key feature of community analysis. Yet in studies of the gut microbiome, bacterial density is rarely reported. Studies of hospitalized patients commonly use rectal swabs for microbiome analysis,… read more here.
Keywords: sequencing contamination; density; rectal swabs; highly variable ... See more keywords
Profiling the Genome-Wide Landscape of Short Tandem Repeats by Long-Read Sequencing
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.810595
Abstract: Background: Short tandem repeats (STRs) are highly variable elements that play a pivotal role in multiple genetic diseases and the regulation of gene expression. Long-read sequencing (LRS) offers a potential solution to genome-wide STR analysis.… read more here.
Keywords: str; genome wide; strs; expression ... See more keywords
Habitat Delineation in Highly Variable Marine Environments
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Marine Science"
DOI: 10.3389/fmars.2019.00112
Abstract: The structure of the phytoplankton community in surface waters is the consequence of complex interactions between physical and chemical properties of the upper water column as well as interaction within the general biological community. Understanding… read more here.
Keywords: highly variable; marine environments; phytoplankton communities; habitat delineation ... See more keywords