N‐glycan engineering of a plant‐produced anti‐CD20‐hIL‐2 immunocytokine significantly enhances its effector functions
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26503
Abstract: Anti‐CD20 recombinant antibodies are among the most promising therapeutics for the treatment of B‐cell malignancies such as non‐Hodgkin lymphomas. We recently demonstrated that an immunocytokine (2B8‐Fc‐hIL2), obtained by fusing an anti‐CD20 scFv‐Fc antibody derived from… read more here.
Keywords: plant; effector functions; glycosylation; anti cd20 ... See more keywords
Modulation of Interleukin-12 activity in the presence of heparin
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05382-1
Abstract: Glycosaminoglycans (GAGs), especially heparin and heparan sulfate (HS), modulate the functions of numerous cytokines. The aims of this multidisciplinary research were to characterize heparin binding to interleukin-12 (IL-12) and determine the mechanism(s) by which heparin… read more here.
Keywords: heparin; activity presence; modulation interleukin; hil ... See more keywords
Engineering a short-chain dehydrogenase/reductase for the stereoselective production of (2S,3R,4S)-4-hydroxyisoleucine with three asymmetric centers
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13978-w
Abstract: Fenugreek is a dietary supplement for anti-aging and human health. (2S,3R,4S)-4-hydroxyisoleucine (4-HIL), which is extracted from fenugreek seeds, is expected to be a promising orally active drug for diabetes and diabetic nephropathy because of its… read more here.
Keywords: production; chain dehydrogenase; short chain; hydroxyisoleucine ... See more keywords
Solution processable mixed-solvent exfoliated MoS2 nanosheets for efficient and robust organic light-emitting diodes
Sign Up to like & getrecommendations! Published in 2018 at "AIP Advances"
DOI: 10.1063/1.5020708
Abstract: We demonstrate the use of solution-processed molybdenum trioxide (MoO3) nanoparticle-decorated molybdenum disulfide (MoS2) nanosheets (MoS2/MoO3) as hole injection layer (HIL) in organic lighting diodes (OLEDs). The device performance is shown to be significantly improved by… read more here.
Keywords: moo3 nanoparticle; hil; moo3; mos2 moo3 ... See more keywords
PSVIII-3 Alternative nutritional evaluation of black soldier fly by substrate in cat diets and its effect on fecal microbiota.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Animal Science"
DOI: 10.1093/jas/skaf300.533
Abstract: This study was conducted to substitute different ratios and substrates of black soldier fly larvae (Hermetia illucens larvae; HIL) to investigate the effect on cats. A total of 30 mixed-sex domestic cats (Felis domestica) with… read more here.
Keywords: cat diets; group; hil; con ... See more keywords
Parametrizable Fixed-Point Arithmetic for HIL With Small Simulation Steps
Sign Up to like & getrecommendations! Published in 2019 at "IEEE Journal of Emerging and Selected Topics in Power Electronics"
DOI: 10.1109/jestpe.2018.2886908
Abstract: Hardware-in-the-loop (HIL) techniques are increasingly used for test purposes because of their advantages over classical simulations. Field-programmable gate arrays (FPGAs) are becoming popular in HIL systems because of their parallel computing capabilities. In most cases,… read more here.
Keywords: hil; fixed point; small simulation; point ... See more keywords
A Novel Platform for Powertrain Modeling of Electric Cars With Experimental Validation Using Real-Time Hardware in the Loop (HIL): A Case Study of GM Second Generation Chevrolet Volt
Sign Up to like & getrecommendations! Published in 2018 at "IEEE Transactions on Power Electronics"
DOI: 10.1109/tpel.2018.2793818
Abstract: This paper presents a novel platform for accurate mathematical modeling of the propulsion system of electric cars. It provides, for the first time, a hardware-in-the-loop (HIL) real-time experimental verification case study of a General Motor… read more here.
Keywords: real time; time; hardware; platform ... See more keywords
Abstract 7279: A novel humanized IL2 and IL15 receptor mouse model enables preclinical efficacy studies for IL-2 cancer therapeutics
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-7279
Abstract: Recombinant human interleukin 2 (IL-2) is effective in treating metastatic renal carcinoma and melanoma, however, severe dose-limiting toxicity restricts patient treatment. There is conflicting evidence from human and murine studies on whether activation of natural… read more here.
Keywords: cancer; mouse model; efficacy; model ... See more keywords
DC-HIL/Gpnmb checkpoint blockade as a synergistic combination for stereotactic ablative radiation (SAbR).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e14129
Abstract: e14129 Background: The combination of radiotherapy (RT)/immunotherapy holds a promise as an innovative cancer treatment. Expansion of myeloid-derived suppressor cells (MDSC) dampens cancer immunity, and DC-HIL receptor is a potent mediator of the suppressor function.… read more here.
Keywords: hil; mdsc; combination; suppressor ... See more keywords
Internal quality assurance of HIL indices on Roche Cobas c702
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0200088
Abstract: Automatic assessment of hemoglobin (H), lipaemia (L) and icterus (I) in serum or plasma (HIL indices) is the mainstay for evaluating sample quality. We planned this study to verify whether in-house prepared internal quality control… read more here.
Keywords: quality assurance; hil; internal quality; hil indices ... See more keywords
microRNA profile of Hermetia illucens (black soldier fly) and its implications on mass rearing
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0265492
Abstract: The growing demands on protein producers and the dwindling available resources have made Hermetia illucens (the black soldier fly, BSF) an economically important species. Insights into the genome of this insect will better allow for… read more here.
Keywords: hil; hil mir; life stages; mir hil ... See more keywords