Determination of thiopurine S‐methyltransferase activity by hydrophilic interaction liquid chromatography hyphenated with mass spectrometry
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DOI: 10.1016/j.jpba.2017.05.016
Abstract: HighlightsNew HILIC‐HPLC‐MS method was developed for determination of TPMT activity.HILIC‐HPLC‐MS combination was approved by excellent performance parameters.HILIC‐HPLC‐MS was compared to traditional RP‐HPLC‐UV as well as advanced RP‐HPLC–MS.Conventional approaches were surpassed in terms of selectivity, LOD,… read more here.
Keywords: hplc; determination; tpmt; liquid chromatography ... See more keywords