Potential antioxidant activity of Morita-Baylis-Hillman adducts.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.03.004
Abstract: The wide variety of potent biological activities of Morita-Baylis-Hillman adducts (MBH) encouraged us to synthesize new series of products belonging to this class of compounds, possessing different functionalities and exhibiting potential antioxidant activity. As part… read more here.
Keywords: antioxidant activity; morita baylis; potential antioxidant; baylis hillman ... See more keywords
The coupling reaction of α-silylamines with Baylis-Hillman adducts by visible light photoredox catalysis
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152746
Abstract: Abstract The preparation of N-containing α,β-unsaturated carboxylate derivatives from α-silylamine and Baylis-Hillman adducts under visible light irradiation was reported. The formation of α-aminoalkyl radical is regioselective compared with the previous reports. The reaction was successfully… read more here.
Keywords: adducts visible; baylis hillman; visible light; coupling reaction ... See more keywords
Baylis-Hillman Adducts as a Versatile Module for Constructing Fluorogenic Release System.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01940
Abstract: The controlled release of a molecule of interest (MOI) is useful in probe design, prodrug construction, and drug delivery. We report herein a versatile thiol-triggered fluorogenic release system using the Baylis-Hillman (BH) adducts as a… read more here.
Keywords: baylis hillman; fluorogenic release; hillman adducts; release system ... See more keywords
Asymmetric Synthesis of 2,3,6-Trisubstituted Piperidines via Baylis–Hillman Adducts and Lithium Amide through Domino Reaction
Sign Up to like & getrecommendations! Published in 2019 at "Synlett"
DOI: 10.1055/s-0039-1690990
Abstract: A convenient asymmetric synthesis of methyl (2S,3S,6R)-6-(4-fluorophenyl)-2-(4-hydroxyphenyl)-piperidine-3-carboxylate is described, starting from Baylis–Hillman adducts. The route involves a domino process: allylic acetate rearrangement, stereoselective Ireland–Claisen rearrangement and asymmetric Michael addition, which provides a δ-amino acid derivative… read more here.
Keywords: hillman adducts; synthesis trisubstituted; baylis hillman; asymmetric synthesis ... See more keywords