Construction of Hydrodibenzo[b,d]furan Frameworks from Morita-Baylis-Hillman Carbonates of Isatins and o-Hydroxy Enones via Palladium and Brønsted Base Relay Catalysis.
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DOI: 10.1021/acs.orglett.1c03689
Abstract: A cascade assembly between isatin-derived Morita-Baylis-Hillman carbonates and o-hydroxybenzylideneacetones has been developed under the relay catalysis of Pd(PPh3)4 and DBU, affording a spectrum of 1,2,3,4-tetrahydrodibenzo[b,d]furan architectures incorporating a spirooxindole motif in moderate to good yields… read more here.
Keywords: hillman carbonates; relay catalysis; morita baylis; baylis hillman ... See more keywords
Phosphine-mediated enantioselective [4 + 1] annulations between ortho-quinone methides and Morita–Baylis–Hillman carbonates
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DOI: 10.1039/c8qo00487k
Abstract: The first example of phosphine catalyzed enantioselective [4 + 1] annulations of ortho-quinone methides and Morita–Baylis–Hillman carbonates is described. In the presence of 1,2-bis[(2R,5R)-2,5-dimethylphospholano]benzene monoxide, Morita–Baylis–Hillman carbonates reacted with ortho-quinone methides smoothly to afford a… read more here.
Keywords: ortho quinone; morita baylis; quinone methides; baylis hillman ... See more keywords
Phosphine-mediated enantioselective [1 + 4]-annulation of Morita–Baylis–Hillman carbonates with 2-enoylpyridines
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DOI: 10.1039/c8ra09453e
Abstract: This work describes a phosphine-catalyzed asymmetric [1 + 4] annulation of Morita–Baylis–Hillman carbonates with 2-enoylpyridines for constructing the enantiomerically enriched 2,3-dihydrofuran motif. In the presence of (−)-1,2-bis[(2R,5R)-2,5-dimethylphospholano]benzene, a series of Morita–Baylis–Hillman carbonates reacted with 2-enoylpyridines… read more here.
Keywords: morita baylis; baylis hillman; hillman carbonates; annulation morita ... See more keywords
Organocatalytic Allylic Amination of Morita–Baylis–Hillman Carbonates
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DOI: 10.1055/s-0037-1611229
Abstract: An organocatalytic asymmetric allylic amination of Morita–Baylis–Hillman carbonates with aromatic amines in the presence of β-isocupreidine is described. Chiral allylic amines were obtained in almost quantitative yields (90–96%) with moderate enantioselectivity. Recrystallization afforded products in… read more here.
Keywords: morita baylis; baylis hillman; hillman carbonates; allylic amination ... See more keywords