Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells.
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DOI: 10.1038/s41588-021-00897-w
Abstract: Driver mutations in genes encoding histone H3 proteins resulting in p.Lys27Met substitutions (H3-K27M) are frequent in pediatric midline brain tumors. However, the precise mechanisms by which H3-K27M causes tumor initiation remain unclear. Here, we use… read more here.
Keywords: disruption prc2; human hindbrain; hindbrain neural; prc2 ... See more keywords