Imaging VEGF Receptors and αvβ3 Integrins in a Mouse Hindlimb Ischemia Model of Peripheral Arterial Disease
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-018-1191-1
Abstract: PurposeTo compare targeted imaging of vascular endothelial growth factor (VEGF) receptors vs. αvβ3 integrins in a mouse hindlimb ischemia model of peripheral artery disease.ProceduresMale wild-type (WT) C57BL/6 mice (8- to 10-week old) (n = 24) underwent left… read more here.
Keywords: vegf receptors; mouse hindlimb; ischemia model; hindlimb ischemia ... See more keywords
The NO-donor MPC-1011 stimulates angiogenesis and arteriogenesis and improves hindlimb ischemia via a cGMP-dependent pathway involving VEGF and SDF-1α.
Sign Up to like & getrecommendations! Published in 2020 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2020.05.012
Abstract: BACKGROUND AND AIMS Peripheral arterial disease (PAD) is an important cause of morbidity and mortality with little effective medical treatment currently available. Nitric oxide (NO) is crucially involved in organ perfusion, tissue protection and angiogenesis.… read more here.
Keywords: angiogenesis arteriogenesis; mpc; mpc 1011; donor mpc ... See more keywords
Naoxintong restores collateral blood flow in a murine model of hindlimb ischemia through PPARδ-dependent mechanism.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2018.08.032
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Naoxintong (NXT) is a compound preparation that is widely used in patients with cardiovascular and cerebrovascular diseases. AIM OF STUDY The aim of this study is to investigate the protective mechanism of NXT… read more here.
Keywords: ppar; blood flow; ischemia; hindlimb ischemia ... See more keywords
Serum metabolomic profiles reveal the impact of BuZangTongLuo formula on metabolic pathways in diabetic mice with hindlimb ischemia.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.112928
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE BuZangTongLuo Formula (BZTLF) was the decoction of eight traditional Chinese medicines including Astragalus membranaceus, Dioscorea opposita, Salvia miltiorrhiza, Scrophularia ningpoensis, Ophiopogon japonicus, Panax ginseng, Fritillariae cirrhosae and Whitmania pigra. This formula has been… read more here.
Keywords: formula; metabolic pathways; hindlimb ischemia; mice hindlimb ... See more keywords
Loss of c‐Kit function impairs arteriogenesis in a mouse model of hindlimb ischemia
Sign Up to like & getrecommendations! Published in 2018 at "Surgery"
DOI: 10.1016/j.surg.2017.10.052
Abstract: Background. Arteriogenesis is a process whereby collateral vessels remodel usually in response to increased blood flow and/or wall stress. Remodeling of collaterals can function as a natural bypass to alleviate ischemia during arterial occlusion. Here… read more here.
Keywords: recovery; hindlimb ischemia; arteriogenesis; kit ... See more keywords
Pro-angiogenic effect of RANTES-loaded polysaccharide-based microparticles for a mouse ischemia therapy
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13444-7
Abstract: Peripheral arterial disease results from the chronic obstruction of arteries leading to critical hindlimb ischemia. The aim was to develop a new therapeutic strategy of revascularization by using biodegradable and biocompatible polysaccharides-based microparticles (MP) to… read more here.
Keywords: pro angiogenic; based microparticles; hindlimb ischemia; polysaccharide based ... See more keywords
Hindlimb Ischemia Impairs Endothelial Recovery and Increases Neointimal Proliferation in the Carotid Artery
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-19136-6
Abstract: Peripheral ischemia is associated with higher degree of endothelial dysfunction and a worse prognosis after percutaneous coronary interventions (PCI). However, the role of peripheral ischemia on vascular remodeling in remote districts remains poorly understood. Here we… read more here.
Keywords: impairs endothelial; endothelial recovery; ischemia; hindlimb ischemia ... See more keywords
Endothelial Hyaluronan Synthase 3 Augments Postischemic Arteriogenesis Through CD44/eNOS Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.315478
Abstract: Supplemental Digital Content is available in the text. Objective: The dominant driver of arteriogenesis is elevated shear stress sensed by the endothelial glycocalyx thereby promoting arterial outward remodeling. Hyaluronan, a critical component of the endothelial… read more here.
Keywords: has3; arteriogenesis; cd44; hyaluronan ... See more keywords
Ischemic-Trained Monocytes Improve Arteriogenesis in a Mouse Model of Hindlimb Ischemia
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.317197
Abstract: Supplemental Digital Content is available in the text. Objective: Monocytes, which play an important role in arteriogenesis, can build immunologic memory by a functional reprogramming that modifies their response to a second challenge. This process,… read more here.
Keywords: arteriogenesis; trained monocytes; ischemic trained; hindlimb ischemia ... See more keywords
Recovery of limb perfusion and function after hindlimb ischemia is impaired by arterial calcification
Sign Up to like & getrecommendations! Published in 2021 at "Physiological Reports"
DOI: 10.14814/phy2.15008
Abstract: Medial artery calcification results from deposition of calcium hydroxyapatite crystals on elastin layers, and osteogenic changes in vascular smooth muscle cells. It is highly prevalent in patients with chronic kidney disease, diabetes, and peripheral artery… read more here.
Keywords: hindlimb ischemia; recovery; calcification; perfusion ... See more keywords
Mesenchymal Stromal Cells Combined With Elastin-Like Recombinamers Increase Angiogenesis In Vivo After Hindlimb Ischemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.918602
Abstract: Hindlimb ischemia is an unmet medical need, especially for those patients unable to undergo vascular surgery. Cellular therapy, mainly through mesenchymal stromal cell (MSC) administration, may be a potentially attractive approach in this setting. In… read more here.
Keywords: hindlimb ischemia; mesenchymal stromal; hindlimb; elastin like ... See more keywords