Overexpression of Zm-HINT1 Confers Salt and Drought Tolerance in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2018 at "Plant Molecular Biology Reporter"
DOI: 10.1007/s11105-018-1081-3
Abstract: Histidine triad nucleotide-binding protein 1 (HINT1) is highly conserved in many species and plays important roles in various biological processes. However, little is known about the responses of HINT1 to abiotic stress in plants. Salt… read more here.
Keywords: salt drought; overexpression hint1; hint1; drought tolerance ... See more keywords
HINT1 deficiency in aged mice reduces anxiety-like and depression-like behaviours and enhances cognitive performances
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2021.111683
Abstract: Histidine triad nucleotide-binding protein 1 (HINT1) is regarded as a haplo-insufficient tumour suppressor and is closely associated with many neuropsychiatric disorders, including major depressive disorders. In addition, HINT1 knockout (KO) mice exhibit anxiolytic-like behaviour, antidepression-like… read more here.
Keywords: hint1 mice; like depression; mice; depression like ... See more keywords
Inhibition of Hint1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00432
Abstract: The interactions between the mu-opioid (MOR) and N-methyl-D-aspartate receptor (NMDAR) constitute an area of intense investigation due to their contributions to maladaptive neuroplasticity. Recent evidence suggests that their association requires the involvement of histidine triad… read more here.
Keywords: tolerance; hint1; nmda; receptor ... See more keywords
HINT1 neuropathy: Expanding the genotype and phenotype spectrum
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Genetics"
DOI: 10.1111/cge.14198
Abstract: Inherited peripheral neuropathy (IPN) is a heterogeneous group of disorders due to pathogenic variation in more than 100 genes. In 2012, the first cases of IPN associated with HINT1 pathogenic variations were described in 33… read more here.
Keywords: spectrum hint1; phenotype; hint1; hint1 neuropathy ... See more keywords
The most common European HINT1 neuropathy variant phenotype and its case studies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2023.1084335
Abstract: HINT1 is an ubiquitous homodimeric purine phosphoramidase belonging to the histidine-triad superfamily. In neurons, HINT1 stabilizes the interaction of different receptors and regulates the effects of their signaling disturbances. Changes in HINT1 gene are associated… read more here.
Keywords: phenotype; hint1; hint1 neuropathy; common european ... See more keywords
Intracellular HINT1-Assisted Hydrolysis of Nucleoside 5′-O-Selenophosphate Leads to the Release of Hydrogen Selenide That Exhibits Toxic Effects in Human Cervical Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23020607
Abstract: In this study, we present a new selenium derivative, 2′-deoxyguanosine-5′-O-selenophosphate (dGMPSe), synthesized by the oxathiaphospholane method and adapted here for the synthesis of nucleoside selenophosphates. Using biochemical assays (HPLC- and fluorescence-based), we investigated the enzymatic… read more here.
Keywords: selenophosphate; hint1; release; hydrogen selenide ... See more keywords